摘要
目的:探讨柳氮磺吡啶联合甲氨蝶呤对类风湿关节炎(RA)患者免疫功能及炎症反应的影响。方法:选取2020年2月~2022年3月期间某院收治的94例RA患者作为研究对象,采用随机数字表法分为对照组和观察组,每组47例。对照组给予甲氨蝶呤等常规抗风湿治疗,观察组在对照组基础上加用柳氮磺吡啶,两组均治疗16周。比较两组患者临床症状[关节压痛数、关节肿胀数、晨僵时间]、炎症反应指标[基质金属蛋白酶-3(MMP-3)、红细胞沉降率(ESR)、C反应蛋白(CRP)]、免疫功能指标[CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]、临床疗效及不良反应发生情况。结果:治疗后,两组患者关节压痛数、关节肿胀数均降低,且观察组低于对照组(P<0.05);晨僵时间均缩短,且观察组短于对照组(P<0.05);MMP-3、ESR、CRP水平均降低,且观察组低于对照组(P<0.05);CD4^(+)、CD4^(+)/CD8^(+)值均升高,且观察组高于对照组(P<0.05);CD8^(+)值均降低,且观察组低于对照组(P<0.05)。两组患者临床治疗总有效率比较无统计学差异(P>0.05);不良反应总发生率比较无统计学差异(P>0.05)。结论:与单用甲氨蝶呤相比,柳氮磺吡啶联合甲氨蝶呤可有效减轻RA患者关节不适感,降低机体炎症反应,改善免疫功能。
Objective:To investigate the impact of sulfasalazine combined with methotrexate on the immune function and inflammatory response of patients with rheumatoid arthritis(RA).Methods:94 patients with RA admitted into a hospital between February 2020 and March 2022 were selected as the research subjects,and they were divided into control group and observation group by the random number table method,with 47 cases in each group.The control group was given routine antirheumatic treatment with methotrexate.The observation group was additionally treated with sulfasalazine on the basis of the control group.Both groups were treated for 16 weeks.The clinical symptoms(tender joint count,swollen joint count,morning stiffness time),inflammatory response indicators[matrix metalloproteinase-3(MMP-3),erythrocyte sedimentation rate(ESR),C reactive protein(CRP)],immune function indicators(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),clinical efficacy and occurrence of adverse reactions were compared between both groups.Results:After treatment,the tender joint count and swollen joint count in both groups were decreased,and the two counts in the observation group were lower compared with that in the control group(P<0.05).The morning stiffness time was shortened in both groups,with a shorter morning stiffness time in the observation group(P<0.05).The levels of MMP-3,ESR and CRP were declined in both groups,which were lower in the observation group(P<0.05).The CD4^(+)and CD4^(+)/CD8^(+)in both groups were enhanced,and the two indicators were higher in the observation group compared with that in the control group(P<0.05).The CD8^(+)was lowered in both groups,and the CD8^(+)in the observation group was lower compared with that in the control group(P<0.05).There was no statistical difference in the overall response rate of treatment was observed between the two groups(P>0.05).The total incidence rate of adverse reactions revealed no statistical difference between the two groups(P>0.05).Conclusion:Compared with methotrexate alone,sulfasalazine combined
作者
王玮玮
陈惠霞
周圆家
马文莉
WANG Wei-wei;CHEN Hui-xia;ZHOU Yuan-jia;MA Wen-li(Department of Nephrology,Rheumatology and Immunology,Central Hospital of Jiaozuo Coal Industry(Group)Co.,Ltd.,Jiaozuo 454000,China)
出处
《中国合理用药探索》
CAS
2023年第12期93-98,共6页
Chinese Journal of Rational Drug Use
关键词
类风湿关节炎
柳氮磺吡啶
甲氨蝶呤
联合治疗
炎症反应
rheumatoid arthritis
sulfasalazine
methotrexate
combined therapy
inflammatory response
