摘要
目的探究在老年胰腺炎患者中运用不同剂量乌司他丁联合谷氨酰胺治疗的临床效果,分析不同治疗方式对患者C反应蛋白和降钙素原指标的影响。方法选择2021年3月至2023年3月我院收治的70例老年胰腺炎患者为研究对象,随机分为两组,每组35例,对照组采用单一谷氨酰胺注射液治疗,试验组采用乌司他丁联合谷氨酰胺治疗,试验组根据使用乌司他丁剂量不同分为三个亚组,分别为A亚组(20万IU,12例)、B亚组(40万IU,12例)、C亚组(60万IU,11例),共治疗14 d。对比各组间临床指标变化、血清学检测指标及用药不良反应情况。结果治疗后,试验组A亚组和对照组各临床指标比较差异无统计学意义(P>0.05),试验组B亚组、C亚组腹痛缓解时间、心率恢复时间、呼吸频率恢复时间短于对照组(P<0.05)。试验组A亚组C反应蛋白(CRP)、白细胞计数(WBC)高于对照组(P<0.05),试验组B亚组和C亚组血清淀粉酶、CRP、WBC水平高于对照组(P<0.05),试验组B亚组血清淀粉酶、WBC水平高于A亚组(P<0.05),试验组C亚组血液淀粉酶、CRP、WBC水平高于A亚组(P<0.05);各组不良反应发生率对比差异无统计学意义(P>0.05)。结论和单一应用谷氨酰胺对比,乌司他丁联合谷氨酰胺治疗老年胰腺炎效果更佳,并且使用不同剂量的乌司他丁临床效果也有所差异,随着用药剂量的提高,对患者C反应蛋白、降钙素原指标影响越大,临床治疗应根据患者具体病情体征开展适宜剂量的治疗。
Objective To investigate the clinical effect of using different doses of ustekin combined with glutamine in elderly pancreatitis patients,and to analyze the effects of different treatment modalities on patients'C-reactive protein and calcitoninogen indexes.Methods Seventy cases of elderly pancreatitis patients admitted to our hospital from March 2021 to March 2023 were selected as study subjects,and were randomly divided into two groups of 35 cases each,the control group was treated with a single glutamine injection,and the experimental group was treated with ustustustadine combined with glutamine,and the experimental group was divided into three subgroups according to the different dosages of ustadine,which were subgroup A(200000 IU,n=12),subgroup B(400000 IU,n=12),and subgroup B(400000 IU,n=12),treated for a total of 14 d.Changes in clinical indexes,serological indexes,and adverse reactions to medication were compared between the groups.Results After treatment,the difference between the clinical indexes of subgroup A of the experimental group and the control group was not statistically significant(P>0.05),and the time of abdominal pain relief,heart rate recovery time,and respiratory rate recovery time of subgroup B and subgroup C of the experimental group was shorter than that of the control group(P<0.05).C-reactive protein(CRP)and white blood cell count(WBC)in subgroup A of the experimental group were higher than those in the control group(P<0.05),and the levels of serum amylase,CRP,and WBC in subgroup B and subgroup C of the experimental group were higher than those in the control group(P<0.05),and the levels of serum amylase and WBC in subgroup B and subgroup C of the experimental group were higher than those in subgroup A(P<0.05),and the blood amylase,CRP,and WBC in subgroup C of the experimental group levels were higher than those of subgroup A(P<0.05);the difference in the incidence of adverse reactions in each group was not statistically significant when compared(P>0.05).Conclusions Compared with the s
作者
颜小珍
YAN Xiaozhen(Jinxian Hospital of Traditional Chinese Medicine,Nanchang 331700,China)
出处
《中国医药指南》
2024年第1期94-96,共3页
Guide of China Medicine
