摘要
目的:评价不同干预方式对2型糖尿病患者治疗依从性的影响。方法:检索中国知网、万方数据库、中国生物医学文献数据库等中文数据库,以及PubMed、EBSCO、Ovid等外文期刊数据库,收集关于中国糖尿病人群管理的临床对照试验的文献。对文献进行质量评价,采用RevMan 5.3软件进行Meta分析。结果:共纳入29篇随机对照研究文献,包括5203例患者。Meta分析显示,药学干预、综合干预及护理干预3种干预方式均可提高治疗依从性[RR=1.22,95%CI(1.12,1.33),P<0.01],有效降低空腹血糖[MD=-1.37 mmol·L^(-1),95%CI(-1.65,-1.10),P<0.01]、餐后2小时血糖[MD=-1.80 mmol·L^(-1),95%CI(-2.26,-1.34),P<0.01]以及糖化血红蛋白[MD=-1.25%,95%CI(-1.56,-0.93),P<0.01]。其中,药学干预方式对治疗依从性的改善率最高[RR=1.27,95%CI(1.19,1.35),P<0.01],对空腹血糖[MD=-1.56 mmol·L^(-1),95%CI(-2.20,-0.93),P<0.01]及餐后2 h血糖[MD=-2.13 mmol·L^(-1),95%CI(-3.28,-0.98),P=0.0003]的改善也优于其他两种干预方式。结论:药学干预、综合干预及护理干预3种干预方式均能提高糖尿病患者治疗依从性,有效改善血糖控制,保持血糖、糖化血红蛋白的稳定。其中药学干预方式见效快,有利于提高患者的治疗依从性,为血糖长期的控制奠定了较好基础。
Objective:To evaluate the effect of different interventions on treatment compliance of patients with type 2 diabetes.Methods:Databases such as PubMed,EBSCO,Ovid,CNKI,WANGFANG DATA and China Biomedical Literature Database were searched to collect literatures on clinical controlled trials on diabetes population management.The literature quality was evaluated,and Meta-analysis was performed using RevMan 5.3 software.Results:A total of 29 randomized controlled trials involving 5203 patients were included.Meta analysis showed that pharmaceutical interventions,comprehensive interventions and nursing interventions all had postive effect on the treatment compliance[RR=1.22,95%CI(1.12,1.33),P<0.01],can effectively reduce fasting blood glucose[MD=-1.37 mmol·L^(-1),95%CI(-1.65,-1.10),P<0.01],2-hour postprandial blood glucose[MD=-1.80 mmol·L^(-1),95%CI(-2.26,-1.34),P<0.01]and HBA1c[MD=-1.25%,95%CI(-1.56,-0.93),P<0.01].Pharmaceutical interventions had better effect on improving treatment compliance[RR=1.27,95%CI(1.19,1.35),P<0.01],improving fasting blood glucose[MD=-1.56 mmol·L^(-1),95%CI(-2.20,-0.93),P<0.01]and 2-hour postprandial blood glucose[MD=-2.13 mmol·L^(-1),95%CI(-3.28,-0.98),P<0.01]than the other two intervention methods.Conclusion:Pharmaceutical interventions,comprehensive interventions and nursing interventions can effectively improve the treatment compliance,help to control blood glucose and maintain the stability of blood glucose and glycated hemoglobin of patients.Among them,pharmacological interventions are conducive to glycemic control with immediate effects,laying the foundation for long-term glycemic control.
作者
王佳芮
张雯倩
杜娟
WANG Jiarui;ZHANG Wenqian;DU Juan(306^(th) Clinical College of PLA,the Fifth Clinical College,Anhui Medical University,Beijing 100101,China;Department of Neurology,Strategic Support Force Medical Center,Beijing 100101,China;Research Department,Strategic Support Force Medical Center,Beijing 100101,China)
出处
《中国医药导刊》
2023年第11期1153-1160,共8页
Chinese Journal of Medicinal Guide
基金
2023年度军队后勤自主科研项目(项目编号:ZZCWS23J1005)。
