摘要
目的:系统评价我国H型高血压中医证型分布频率。方法:对PubMed、Web of science、维普中文期刊数据库、万方数据知识服务平台数据库、中国国家知识基础设施数据库进行检索。检索时限均为建库至2022年11月4日。结果:共纳入18篇合格中文文献,无英文文献,纳入研究对象共4 020例。Meta分析结果显示,肝火亢盛证分布频率为0.21[95%置信区间(CI)(0.18,0.23)],阴虚阳亢证分布频率为0.23[95%CI(0.18,0.29)],痰湿壅盛证分布频率为0.35[95%CI(0.30,0.40)],阴阳两虚证分布频率为0.19[95%CI (0.14,0.26)]。亚组分析显示:在文献质量评价亚组中,痰湿壅盛证在分布情况上的差异有统计学意义(P <0.05),其余证型在分布情况上的差异无统计学意义(P> 0.05);肝火亢盛证、阴虚阳亢证、痰湿壅盛证、阴阳两虚证的分布情况在南北地域方面的差异无统计学意义(P> 0.05)。结论:我国的H型高血压证型分布由少到多依次为阴阳两虚证、肝火亢盛证、阴虚阳亢证、痰湿壅盛证;其中痰湿壅盛证与H型高血压之间密切相关,并且可能为H型高血压的高危证型。由于受到纳入研究数量、质量的影响,以及有发表偏倚存在的可能,上述结论需要通过进一步扩大样本量及纳入更多高质量的研究加以验证。
Objective:To systematically review the distribution frequency of traditional Chinese medicine(TCM)syndromes of H-type hypertension in China.Methods:Databases of PubMed,Web of science,VIP Chinese Journal Database,Wanfang Database,China National Knowledge Infrastructure Database(CNKI)were retrieved.The retrieval time was from the establishment of the database to November 4,2022.Results:A total of 18 qualified Chinese studies were included,with no English literature,and a total of 4020 subjects were included in the study.The results of Meta-analysis showed that the distribution frequency of syndrome of hyperactivity of liver fire was 0.21[95%CI(0.18,0.23)],the distribution frequency of syndrome of Yin(阴)deficiency and Yang(阳)hyperactivity was 0.23[95%CI(0.18,0.29)],and the distribution frequency of syndrome of excessive phlegm-dampness was 0.35[95%CI(0.30,0.40)].The distribution frequency of Yin-Yang deficiency syndrome was 0.19[95%CI(0.14,0.26)].Subgroup analysis showed that in the subgroup of literature quality evaluation,there was a statistical significance in the distribution of syndrome of excessive phlegm-dampness(P<0.05),while there was no statistical significance in the distribution of other syndrome types(P>0.05).There was no significant difference in the distribution of syndrome of hyperactivity of liver fire,syndrome of Yin deficiency and Yang hyperactivity,syndrome of excessive phlegm-dampness and syndrome of Yin-Yang deficiency in the north and south regions(P>0.05).Conclusions:The distribution of H-type hypertension syndromes in China is Yin-Yang deficiency syndrome,liver fire hyperactivity syndrome,Yin deficiency and Yang hyperactivity syndrome,excessive phlegm-dampness syndrome in the order of from less to more.The syndrome of excessive phlegm-dampness is closely related to H-type hypertension,and may be a high-risk syndrome of H-type hypertension.Due to the influence of the quantity and quality of included studies,as well as the possibility of publication bias,the above conclusions need to be ve
作者
王淑荣
杨娜
苑宁
张晋铭
史萌萌
于春霞
杜铁民
WANG Shurong;YANG Na;YUAN Ning;ZHANG Jinming;SHI Mengmeng;YU Chunxia;DU Tiemin
出处
《中医临床研究》
2023年第30期61-67,共7页
Clinical Journal Of Chinese Medicine
基金
烟台地区H型高血压老年患者中医体质分布及血压昼夜节律相关性临床研究,山东省中医药科技重点项目(Z-2022017)。
关键词
H型高血压
中医证型
META分析
分布频率
痰湿壅盛证
H-type hypertension
TCM types of syndrome
Meta-analysis
Distribution frequency
Syndrome of excessive phlegm-dampness
