摘要
目的探讨超光子联合氢醌乳膏治疗黄褐斑的疗效与安全性。方法2020年1月至2022年10月,在华中科技大学协和深圳医院皮肤科就诊的女性黄褐斑患者30例,年龄28~54(38.6±6.5)岁;将其分为3组,每组10例,分别为联合治疗组、超光子组及氢醌组。联合治疗组用超光子联合氢醌治疗,超光子组仅用超光子治疗,氢醌组仅用氢醌乳膏治疗。治疗4个月后比较分析3组疗效和安全性。结果治疗结束后,联合治疗组有效10例、超光子组有效5例、氢醌组有效2例,联合治疗组总有效率高于超光子组和氢醌组,差异有统计学意义(P<0.05)。3组治疗后平均黄褐斑面积及严重指数评分值均较治疗前下降(均P<0.05),其中联合治疗组治疗后黄褐斑面积及严重指数评分低于治疗后的氢醌组,差异有统计学意义(P<0.05)。所有患者未见严重不良反应。结论超光子及氢醌乳膏单独治疗均能改善黄褐斑,但超光子联合氢醌乳膏效果更佳。
Objective To observe the efficacy and safety of ultra photon intense pulsed light combined with hydroquinone cream for the treatment of chloasma.Methods From January 2020 to October 2022,a total of 30 patients with chloasma treated in the Department of Dermatology,Huazhong University of Science and Technology Union Shenzhen Hospital,ranged from 28 to 54 years old with an average age of 39 years,were randomly divided into three groups with 10 patients in each group:combined treatment group was treated with ultra photon intense pulsed light combined with hydroquinone cream;ultra photon intense pulsed light group was treated with ultra photon intense pulsed light alone;hydroquinone group was treated with hydroquinone cream alone.The efficacy and safety of the three groups were compared after four months of treatment.Results After the treatment,10 cases were effective in the combined treatment group,5 cases were effective in the ultra photon intense pulsed light group and 2 cases were effective in the hydroquinone group.The total effective rate of the combined treatment group was significantly better than that of the ultra photon intense pulsed light group and the hydroquinone group,with statistical significance(P<0.05).The average melasma area severity index score of the three groups after treatment was significantly decreased compared with that before treatment respectively(P<0.05),and the average melasma area severity index score of the combined treatment group after treatment was significantly lower than that of hydroquinone group,with statistical significance(P<0.05).No serious adverse reactions were observed in all the patients.Conclusions Ultra photon intense pulsed light and hydroquinone cream can improve chloasma alone,but ultra photon intense pulsed light combined with hydroquinone cream has better therapeutic effect.
作者
黄显
许嘉璐
邓婷
柴宝
Huang Xian;Xu Jialu;Deng Ting;Chai Bao(Department of Dermatology,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen 518052,China)
出处
《中华医学美学美容杂志》
2023年第6期434-438,共5页
Chinese Journal of Medical Aesthetics and Cosmetology
基金
深圳市南山区科技计划项目(2020035)。
关键词
黄褐斑
超光子
氢醌乳膏
疗效
Chloasma
Ultra photon intense pulsed light
Hydroquinone cream
Clinic efficacy
