摘要
目的对比慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并真菌感染(fungal infections,FI)患者使用真菌试验、G试验的诊断结果。方法研究对象100例为2021年8月至2022年8月郑州市第一人民医院收治且有不同程度咳嗽咳痰、发热、心力衰竭、呼吸衰竭、电解质紊乱等COPD合并FI疑似症状的患者。所有患者均行G实验、真菌实验,金标准为组织病理学,对比两种检测方法的阳性检出率、敏感度、特异度、准确度,对比单纯COPD患者和COPD合并FI患者的1,3-β-D葡聚糖(BDG)浓度。受试者工作特征曲线(ROC)比较G实验与真菌实验的预测效能。结果100例疑似COPD合并FI患者:组织病理学检测结果[阳性75例(75.00%),阴性25例(25.00%)];G实验阳性检出率、敏感度、特异度高于真菌实验,但差异无统计学意义(P>0.05);G实验准确度高于真菌实验(P<0.05);ROC曲线分析显示,G实验预测COPD合并FI的曲线下面积(AUC)为0.867,大于真菌实验的0.733,差异有统计学意义(Z=3.078,P=0.002)。单纯COPD患者的BDG浓度(712.53±70.68)pg/L低于COPD合并FI患者(859.62±85.37)pg/L,组间对比有统计学意义(P<0.05)。结论G实验能提高早期诊断COPD合并FI的准确率。
Objective To compare the diagnostic results of fungal test and G test in patients with chronic obstructive pulmonary disease(COPD)complicated with fungal infections(FI).Methods The study subjects were 100 COPD patients with FI suspected symptoms,such as cough and expectoration,fever,heart failure,respiratory failure,and electrolyte disturbance,who were admitted to the First People’s Hospital of Zhengzhou from August 2021 to August 2022.All patients underwent G test and fungal test,the gold standard was histopathology,the positive detection rate,sensitivity,specificity,and accuracy of the two detection methods were compared,and the concentration of 1,3-beta-D glucan(BDG)was compared between patients with simple COPD and patients with COPD complicated with FI.Receiver Operating Characteristic curve(ROC)was used to compare the predictive efficiency of G test and fungal test.Results In 100 suspected COPD patients complicated with FI,the results of histopathological test showed that 75 cases(75.00%)were positive and 25 cases(25.00%)were negative;The positive detection rate,sensitivity,and specificity of G test were higher than fungal test but the difference was not statistically significant(P>0.05);The accuracy of G test was higher than fungal test(P<0.05);ROC curve analysis showed that the area under the curve(AUC)for predicting COPD complicated with FI was 0.867 in G test,it was higher than 0.733 of fungal test,and the difference was statistically significant(Z=3.078,P=0.002).The concentration of BDG in patients with single COPD(712.53±70.68)pg/L was lower than patients with COPD complicated with FI(859.62±85.37)pg/L,the comparison between groups was statistically significant(P<0.05).Conclusion G test can improve the accuracy of early diagnosis for COPD complicated with FI.
作者
刘岚宁
周冰
刘俊
Liu Lanning;Zhou Bing;Liu Jun(Department of Laboratory,The First People’s Hospital of Zhengzhou,Zhengzhou 450000,Henan,China)
出处
《右江民族医学院学报》
2023年第6期909-912,917,共5页
Journal of Youjiang Medical University for Nationalities
关键词
肺疾病
慢性阻塞性
真菌感染
真菌试验
G实验
lung disease,chronic obstructive
fungal infection
fungal test
G test
