摘要
目的探讨剪切波弹性成像(shear wave elastography,SWE)在过敏性紫癜(Henoch-Schonlein purpura,HSP)儿童肾脏中的价值。方法选取2021年11月~2022年8月温州医科大学附属第二医院收治的59例HSP儿童,分为单纯HSP组29例和紫癜性肾炎(Henoch-Schonlein purpura nephritis,HSPN)组30例。另选取同期健康儿童50例作为对照组,比较3组间右肾皮质和髓质杨氏模量(Young′s modulus,YM)值。绘制受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)评估SWE对单纯HSP的诊断效能。并对右肾皮质和髓质YM值与相关指标进行相关性分析和多元线性回归分析。结果3组间右肾皮质和髓质YM值比较,差异有统计学意义(P<0.05)。其中单纯HSP组右肾皮质YM值高于对照组及HSPN组(P<0.05)。单纯HSP组右肾髓质YM值高于对照组(P<0.05)。右肾皮质YM值比右肾髓质YM值对单纯HSP的诊断效能更好。右肾皮质和髓质YM值均与右肾体积有线性回归关系。结论HSP儿童肾脏受累且影响生理功能前右肾皮质和髓质YM值已高于健康儿童,随着病变进展,YM值有所下降,SWE有可能成为HSP儿童肾脏受累常规筛查及随访监测的新技术。
Objective To explore the value of shear wave elastography(SWE)in the kidneys of children with Henoch-Schonlein purpura(HSP).Methods A total of 59 cases with HSP admitted to the Second Affiliated Hospital of Wenzhou Medical University from November 2021 to August 2022 were selected and divided into simple HSP group(29 cases)and Henoch-Schonlein purpura nephritis(HSPN)group(30 cases).50 normal children during the same period were included as control group.The Young′s modulus(YM)of right renal cortex and medulla were compared among the three groups.receiver operating characteristic curve(ROC curve)was plotted to evaluate the diagnostic efficiency of SWE for simple HSP.Correlation analysis and multiple linear regression analysis were performed for the YM value of right renal cortex and medulla of all children with HSP and related indexes.Results There was statistical significance in YM values of right renal cortex and medulla among the three groups(P<0.05).The YM value of right renal cortex of the simple HSP group was higher than that in the control group and HSPN group(P<0.05).The YM value of right renal medulla of the simple HSP group were higher than that in the control group(P<0.05).The YM value of right renal cortex was better than the YM value of right renal medulla in the diagnostic efficiency of simple HSP.The YM value of right renal cortex and medulla both had a linear regression relationship with the right renal volume.Conclusion The YM value of right renal cortex and medulla were higher than those of healthy children,with the progression of the disease the YM values decreasing.It may become a new technology for routine screening and follow-up monitoring of renal involvement in children with HSP.
作者
崔晓颖
占小梅
徐茂晟
邹春鹏
CUI Xiaoying;ZHAN Xiaomei;XU Maosheng(Department of Ultrasound,The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang 325027,China)
出处
《医学研究杂志》
2023年第11期133-136,141,共5页
Journal of Medical Research
基金
浙江省温州市科技局基础性科研项目(Y20220452)。
关键词
剪切波弹性成像
过敏性紫癜
肾脏
Shear wave elastography
Henoch-Schonlein purpura
Kindey
