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凝血指标变化与多发伤所致肺部感染并急性呼吸窘迫综合征患者预后关系分析

Analysis of the Relationship between the Changes of Coagulation Index and the Prognosis of Patients with Pulmonary Infection Caused by Multiple Injuries and Acute Respiratory Distress Syndrome
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摘要 目的:探讨凝血指标变化与多发伤所致肺部感染并急性呼吸窘迫综合征患者预后关系分析。方法:共纳入2019年8月至2020年12月121例多发伤患者,入组时收集了完整的人口统计学特征和临床实验室基线数据。据简易临床肺部感染评分(sCPIS)将其患者分为肺部感染组(n=62)和非肺部感染组(n=59)。根据28d死亡率,将多发伤所致肺部感染并急性呼吸窘迫综合征(ARDS)患者分为生存组(n=31)和死亡组(n=31)。单因素方差分析评估有无肺部感染以及生存组及死亡组的人口统计学特征和临床实验室基线间的差异,Logisitic回归和ROC曲线分析多发伤所致肺部感染并ARDS患者的SOFA评分、PT、FDP、D-D和住ICU时间的预测价值。结果:121例多发伤患者多发伤所致肺部感染并ARDS为62例。肺部感染患者的SOFA评分,APTT,INR,AT-Ⅲ,住ICU时间和28d死亡率高于非肺部感染,多发伤所致肺部感染并ARDS死亡组SOFA评分,PT,FDP,D-D高于生存组(P<0.01)。Logisitic回归和ROC曲线分析PT是多发伤所致肺部感染并ARDS患者的预后因素,其ROC曲线面积为0.737,差异有统计学意义(P<0.05)。结论:本研究表明多发伤所致肺部感染并ARDS死亡组凝血指标高于生存组,表明多发伤所致肺部感染并ARDS的凝血功能障碍,其PT对多发伤所致肺部感染并ARDS患者的预警价值。 Objective:To explore the relationship between the changes of coagulation index and the prognosis of patients with pulmonary infection caused by multiple injuries and acute respiratory distress syndrome.Methods:From August 2019 to December 2020,a total of 121 patients with multiple injuries were enrolled,and complete demographic characteristics and clinical laboratory baseline data were collected at the time of enrollment.According to the Simple Clinical Pulmonary Infection Score(sCPIS),the patients were divided into lung infection group(n=62)and non-pulmonary infection group(n=59).According to the 28-day mortality rate,patients with lung infection caused by multiple injuries and ARDS were divided into survival group(n=31)and death group(n=31).One-way analysis of variance assesses the presence or absence of lung infection and the difference between the demographic characteristics of the survival group and the death group and the clinical laboratory baseline.Logisitic regression and ROC curve analyze the SOFA score of patients with lung infection caused by multiple injuries and ARDS,The predictive value of PT,FDP,DD and ICU stay.Results:There were 121 patients with multiple injuries and 62 patients with pulmonary infection caused by multiple injuries and ARDS.The SOFA score,APTT,INR,AT-Ⅲ,ICU stay and 28-day mortali-ty of patients with lung infection were higher than those of non-pulmonary infections,and SOFA scores,PT,FDP,PT,FDP,pulmonary infection caused by multiple injuries and ARDS death group,DD and higher than survival group(P<0.01).Logisitic regression and ROC curve analysis PT is a prognostic factor for patients with lung infection caused by multiple injuries and ARDS.The ROC curve area is 0.737,and the difference is statistically significant(P<0.05).Conclusion:This study showed that the coagulation index of the lung infection caused by multiple injuries and ARDS death group was higher than that of the survival group.Early warning values.
作者 干魁 李子文 李国军 杨骞 GAN Kui(Changsha Third Hospital,Hunan Changsha 410035,China)
出处 《河北医学》 CAS 2023年第12期2072-2076,共5页 Hebei Medicine
基金 湖南省卫生健康委员会科研项目(编号:20210196)。
关键词 肺部感染 凝血指标 多发伤 急性呼吸窘迫综合征 Blood coagulation index Multiple injuries Lung infection ARDS
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