摘要
目的:观察高压氧联合丁苯酞对急性脑梗死患者神经功能及血清Ang-1、THBS-1和Bcl-2水平的影响。方法:前瞻性选取2021年5月至2023年1月收治的112例急性脑梗死患者为研究对象,采用完全随机法分为两组。两组均给予常规药物治疗,丁苯酞组56例给予丁苯酞治疗,高压氧组56例给予高压氧联合丁苯酞治疗。比较两组美国国立卫生研究院脑卒中量表(NIHSS)评分、Barthel(BI)指数、改良Rankin量表(mRS)评分的差异,检测两组脑血流灌注、Ang-1、THBS-1、Bcl-2的水平,统计两组疗效和不良反应。结果:两组治疗前相关评分比较,差异无统计学意义(P>0.05)。与本组治疗前比较,高压氧组和丁苯酞组NIHSS评分、mRS评分均降低,BI指数均升高,高压氧组降低及升高幅度大于丁苯酞组(P<0.05)。两组治疗前脑血流灌注比较,差异无统计学意义(P>0.05)。与本组治疗前比较,高压氧组和丁苯酞组脑血流量(CBF)、脑血容量(CBV)均升高,高压氧组升高幅度大于丁苯酞组(P<0.05)。两组治疗前Ang-1、THBS-1、Bcl-2比较,差异无统计学意义(P>0.05)。与本组治疗前比较,高压氧组和丁苯酞组Ang-1、Bcl-2均升高,THBS-1均降低高压氧组升高及降低幅度大于丁苯酞组(P<0.05)。高压氧组总有效率为94.64%(53/56),高于丁苯酞组的82.14%(46/56),不良反应与丁苯酞组比较,差异无统计学意义(P>0.05)。结论:高压氧联合丁苯酞对急性脑梗死可改善脑血流灌注,调节Ang-1、THBS-1、Bcl-2的表达,改善神经功能,提高患者独立性。
Objective:To observe the effects of hyperbaric oxygen combined with butylphthalide on neurological function and serum levels of Ang-1,THBS-1,and Bcl-2 in patients with acute ischemic stroke.Methods:A total of 112 patients with acute ischemic stroke admitted from May 2021 to January 2023 were prospectively selected as the study subjects and divided into two groups using a completely random method.Both groups received conventional medication,with 56 patients in the Butylphthalide group receiving butylphthalide treatment and 56 patients in the Hyperbaric Oxygen group receiving hyperbaric oxygen combined with butylphthalide treatment.The differences in NIHSS score,Barthel Index(BI),and modified Rankin Scale(mRS)score between the two groups were compared.Additionally,brain blood flow perfusion,levels of Ang-1,THBS-1,and Bcl-2 were detected,and treatment efficacy and adverse reactions were statistically analyzed.Results:There was no statistically significant difference in the relevant scores before treatment in both groups(P>0.05).Compared with before treatment,the NIHSS and mRS scores decreased,while the BI index increased in both the Hyperbaric Oxygen and Butylphthalide groups,with greater reductions and increases observed in the Hyperbaric Oxygen group than in the Butylphthalide group(P<0.05).There was no statistically significant difference in brain blood flow perfusion before treatment between the two groups(P>0.05).Compared with before treatment,both the Hyperbaric Oxygen and Butylphthalide groups showed an increase in cerebral blood flow(CBF)and cerebral blood volume(CBV),with a greater increase observed in the Hyperbaric Oxygen group than in the Butylphthalide group(P<0.05).There was no statistically significant difference in Ang-1,THBS-1,and Bcl-2 levels before treatment between the two groups(P>0.05).Compared with before treatment,both the Hyperbaric Oxygen and Butylphthalide groups showed an increase in Ang-1 and Bcl-2 levels,and a decrease in THBS-1 levels,with a greater increase and decrease observed in th
作者
李娜
王圣元
孟祥恩
LI Na;WANG Shengyuan;MENG Xiangen(Sixth Medical Center,PLA General Hospital,Beijing 100048,China)
出处
《河北医学》
CAS
2023年第12期2011-2016,共6页
Hebei Medicine
基金
北京市科技计划课题(编号:Z191100006619028)
首都医科大学2022年度科技计划、社科计划一般项目(编号:KM202210025002)。
关键词
高压氧
丁苯酞
急性脑梗死
脑血流灌注
神经功能
Hyperbaric oxygen
Butylphthalein
Acute cerebral infarction
Cerebral blood perfusion
Neural function
