摘要
目的探讨苓桂三子汤联合雷火灸治疗痰湿阻肺型慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法选取2020年1月至2022年7月该院急诊科及呼吸内科收治的90例AECOPD患者进行前瞻性随机对照研究,按随机数字表法分为对照组和观察组,每组45例。对照组给予常规西药治疗,观察组在对照组基础上加用苓桂三子汤联合雷火灸治疗,均连续治疗2周。比较两组临床疗效、不良反应,治疗前、后中医证候积分、炎症指标[白细胞介素-8(IL-8)、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)]及动脉血气分析指标[动脉血氧饱和度(SaO_(2))、血氧分压(PaO_(2))、血二氧化碳分压(PaCO_(2))]水平。结果治疗2周后,观察组治疗总有效率为97.78%,明显高于对照组的82.22%(P<0.05)。治疗2周后,两组患者各证候积分、IL-8、WBC、hs-CRP水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);SaO_(2)、PaO_(2)高于治疗前,PaCO_(2)低于治疗前,且观察组较对照组变化更明显,差异有统计学意义(P<0.05)。两组患者治疗期间均未发生明显不良反应。结论苓桂三子汤联合雷火灸治疗AECOPD疗效较好,可有效改善患者血气,减轻炎症反应,安全性好。
Objective To investigate the clinical effect of Linggui Sanzi Decoction combined with thunder fire moxibustion in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) of phlegm-dampness obstructing lung type.Methods A prospective randomized controlled study was conducted on 90 patients with AECOPD admitted to emergency department and respiratory department of the hospital from January 2020 to July 2022.They were divided into the control group and the observation group according to the random number table method,with 45 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Linggui Sanzi Decoction combined with thunder fire moxibustion on the basis of the control group for two consecutive weeks.The clinical efficacy,adverse reactions,TCM syndrome scores,inflammatory indexes [interleukin-8(IL-8),white blood cell count(WBC),high-sensitivity C-reactive protein(hs-CRP)] and arterial blood gas analysis indexes [arterial oxygen saturation(SaO_(2)),blood oxygen partial pressure(PaO_2),blood carbon dioxide partial pressure(PaCO_(2))] before and after treatment were compared between the two groups.Results After two weeks of treatment,the total effective rate of the observation group was 97.78%,which was significantly higher than 82.22% of the control group(P<0.05).After two weeks of treatment,the scores of each syndrome,IL-8,WBC and hs-CRP levels in the two groups were lower than those before treatment,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).SaO_(2) and PaO_(2) were higher than those before treatment,PaCO_(2) was lower than that before treatment,and the changes in the observation group were more obvious than those in the control group,the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the two groups during the treatment.Conclusion Linggui Sanzi Decoction combined with thunder fire moxibustion
作者
陈威
欧阳国林
冯原
CHEN Wei;OUYANG Guolin;FENG Yuan(Department of Emergency,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning,Guangxi 530000,China;Department of Respiratory,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning,Guangxi 530000,China)
出处
《重庆医学》
CAS
2023年第24期3760-3764,共5页
Chongqing medicine
基金
广西壮族自治区中医药管理局自筹科研经费项目(GXZYA20220092)。
关键词
慢性阻塞性肺疾病
急性加重
苓桂三子汤
雷火灸
炎症
血气
chronic obstructive pulmonary disease
acute exacerbation
Linggui Sanzi Decoction
thunder fire moxibustion
inflammation
blood gas
