摘要
目的 研究补肾活血方在血栓前状态致复发性流产患者中的应用效果。方法 将2019年1月至2021年6月河南中医药大学第一附属医院生殖医学科收治的104例血栓前状态致复发性流产患者根据随机数字表法分为西药治疗组和联合中药方剂组,各52例。西药治疗组接受阿司匹林及低分子肝素钙治疗,联合中药方剂组在西药治疗组的基础上接受补肾活血方治疗,两组均治疗3个月,并随访至患者分娩或流产。统计两组3个月后的临床疗效及随访期间妊娠结局,比较两组治疗前及治疗3个月后中医证候积分、血小板功能、凝血因子、子宫血流参数及子宫内膜厚度。结果 治疗3个月后,联合中药方剂组治疗总有效率高于西药治疗组(P<0.05);两组腰膝酸软(冷)、少腹疼痛、阴道流血、出血色暗或夹血块、面色晦暗、头晕耳鸣、夜尿频多评分、血清血小板α颗粒膜糖蛋白-140(GMP-140)、纤维蛋白原降解产物(FDP)水平及子宫动脉阻力指数(RI)、搏动指数(PI)、子宫动脉收缩末期峰值与舒张末期峰值比值(S/D)均降低,联合中药方剂组低于西药治疗组(P<0.05);联合中药方剂组外周血血小板聚集功能(PAF)、血小板聚集率(PagT)降低,且低于西药治疗组(P<0.05);两组部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)延长,联合中药方剂组长于西药治疗组(P<0.05);两组子宫内膜厚度增厚,联合中药方剂组厚于西药治疗组(P<0.05)。随访期间,联合中药方剂组活产率高于西药治疗组(P<0.05)。结论 补肾活血方联合阿司匹林及低分子肝素钙治疗血栓前状态致复发性流产可有效改善患者中医证候,调节机体血小板功能及凝血功能,改善子宫血流情况、子宫内膜厚度及妊娠结局,疗效较好。
Objective To study the effect of Bushen Huoxue prescription in patients with recurrent abortion caused by prethrombotic state.Methods A total of 104 patients with recurrent miscarriage caused by pre thrombotic state admitted to the Reproductive Medicine Department of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2019 to June 2021 were randomly divided into Western medicine treatment group and combined with Chinese medicine prescription group,with 52 patients in each group,based on a random number table method.The Western medicine treatment group was treated with aspirin and low molecular weight heparin calcium,and the combined with Chinese medicine prescription group was treated with Bushen Huoxue prescription on the basis of the Western medicine treatment group.Both groups were treated for 3 months and followed up until delivery or abortion.Clinical efficacy of the two groups after 3 months of treatment and pregnancy outcome during follow-up were analyzed.The traditional Chinese medicine syndrome scores,platelet function,coagulation factors,uterine blood flow parameters and endometrial thickness were compared between the two groups before and after 3 months of treatment.Results After 3 months of treatment,the total effective rate of combined with Chinese medicine prescription group was higher than that of Western medicine treatment group(P<0.05).After 3 months of treatment compared to before treatment,the scores of lumbar and knee pain(cold),less abdominal pain,vaginal bleeding,dark blood color or clots,dark face,dizziness,tinnitus,nocturnal frequent urination,levels of serum plateletαgranule membrane glycoprotein-140(GMP-140),fibrinogen degradation products(FDP),uterine artery resistance index(RI),pulsation index(PI)and the ratio of end-systolic peak to end-diastolic peak(S/D)of uterine artery in the two groups all decreased,and the combined with Chinese medicine prescription group was lower than the Western medicine treatment group(P<0.05).The platelet aggregat
作者
于喜乐
卫爱武
崔天薇
肖惠冬子
宋红艳
YU Xile;WEI Aiwu;CUI Tianwei;XIAO Huidongzi;SONG Hongyan(Reproductive Medicine Department,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;the First Clinical College,Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2023年第22期4178-4183,共6页
Henan Medical Research
关键词
复发性流产
血栓前状态
补肾活血方
阿司匹林
低分子肝素钙
疗效
recurrent abortion
prethrombotic state
Bushen Huoxue prescription
aspirin
low molecular weight heparin calcium
curative effect
