摘要
Alzheimer’s disease(AD)is the most common form of dementia-the 7th leading cause of death worldwide.At the tissue level,AD is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of tau.Molecular genetics of early-onset AD and longitudinal brain-imaging studies of late-onset AD indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).
基金
supported by the National Institutes of Health through grant R15AG055043 to NDL and also by the Lise Ann and Leo Beaver’s endowment to Clark University.
