摘要
目的:探究不同镇痛模式应用于慢性非癌性疼痛患者的镇痛效果。方法:选择2021年8月—2022年9月于启东市人民医院接受治疗的120例慢性非癌性疼痛患者为研究对象,分为研究组(n=60,接受综合镇痛)与对照组(n=60,单纯接受药物镇痛),比较两组患者的治疗效果。结果:两组患者接受治疗后电痛阈及温度痛阈均较治疗前升高(均P<0.05),研究组患者电痛域及温度痛域均明显高于对照组(7.91±0.41 mA vs 7.21±0.39 mA,48.23±1.65℃vs 47.01±1.55℃,均P<0.05)。两组患者治疗后汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分均较治疗前降低(均P<0.05),研究组HAMA和HAMD均明显低于对照组(7.12±1.56分vs 9.89±2.08分,8.12±2.14分vs 10.23±2.98分,均P<0.05)。两组患者治疗后血清β-内啡肽(β-EP)、促肾上腺皮质激素(ACTH)及皮质醇(COR)水平较治疗前降低,研究组β-EP、ACTH及COR均明显低于对照组(均P<0.05)。研究组不良反应发生率低于对照组(10%vs 25%,P<0.05)。结论:采取综合镇痛措施治疗慢性非癌性疼痛患者,可提高电痛阈和温度痛阈,改善焦虑抑郁等不良情绪,降低炎症因子及不良反应发生率。
Objective:To explore the analgesic effects of different modes on patients with chronic noncancerous pain.Methods:A total of 120 patients with chronic non-cancerous pain who received treatment in Qidong People's Hospital from August 2021 to September 2022 were selected as the study subjects and divided into the study group(n=60,receiving comprehensive analgesia)and the control group(n=60,receiving drug analgesia alone).The therapeutic effects of the two groups were compared.Results:After treatment,the electric pain threshold and temperature pain threshold were both higher than those before treatment(both P<0.05),which increased much more significantly in the study group compared to the control group(7.91±0.41 mA vs 7.21±0.39 mA,48.23±1.65℃vs 47.01±1.55℃,both P<0.05).The scores of Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)in both groups were lower after treatment than before(both P<0.05).HAMA and HAMD in the study group were significantly decreased than those in the control group(7.12±1.56 vs 9.89±2.08,8.12±2.14 vs 10.23±2.98,both P<0.05).After treatment,the serum levels ofβ-endorphin(β-EP),adrenocorticotropin(ACTH)and cortisol(COR)were reduced,which were more lower in the study group than those in the control group(all P<0.05).The incidence of adverse reactions was lower in the study group,when compared to the control group(10%vs 25%,P<0.05).Conclusion:Taking comprehensive analgesic measures to treat patients with chronic non-cancerous pain can improve electric pain threshold and temperature pain threshold,alleviate anxiety and depression,and reduce inflammatory factors and incidence of adverse reactions.
作者
张国波
袁萍
Zhang Guobo;Yuan Ping(Department of Anesthesiology,Qidong People's Hospital,Qidong 226200,China)
出处
《巴楚医学》
2023年第4期70-74,共5页
Bachu Medical Journal
基金
南通市卫健委科研项目(No:QB2020023)。
关键词
慢性非癌性疼痛
镇痛模式
电痛阈
温度痛阈
chronic non-cancerous pain
analgesic mode
electric pain threshold
temperature pain threshold
