摘要
目的 分析复方曲肽注射液联合胞磷胆碱钠注射液治疗急性脑梗死(ACI)对患者神经功能及对内皮生长因子(VEGF)、血栓素A2(TXA2)、基质金属蛋白酶-9(MMP-9)的影响。方法 依随机数字表法将周口市中心医院2020年7月至2023年1月收治的106例ACI患者分为参照组(给予胞磷胆碱钠注射液)、研究组(给予复方曲肽注射液+胞磷胆碱钠注射液),每组各53例。两组均给予常规治疗,连续治疗14 d。比较两组疗效,治疗前后神经功能[美国国立卫生研究院卒中量表(NIHSS)评估]评分,生活能力[改良Rankin量表(m RS)评估]评分、微循环指标(VEGF、TXA2、MMP-9),炎症因子[超敏C反应蛋白(hs-CRP)、单核细胞趋化蛋白1(MCP-1)、白细胞介素-1β(IL-1β)、IL-18]水平及酪氨酸蛋白激酶2(JAK2)/转录激活因子3(STAT3)信号通路蛋白水平。结果 连续治疗14 d,研究组总有效率92.45%高于参照组77.36%(P<0.05)。治疗后,研究组NIHSS、m RS评分均低于参照组(P<0.05);研究组VEGF高于参照组,TXA2、MMP-9低于参照组(P<0.05);研究组hs-CRP、MCP-1、IL-1β、IL-18均低于参照组(P<0.05);研究组JAK2、P-JAK2、STAT3、P-STAT3均低于参照组(P<0.05)。研究组不良反应发生率与参照组相比,差异无统计学意义(P>0.05)。结论 采用复方曲肽注射液联合胞磷胆碱钠注射液治疗ACI疗效确切,有效减轻炎症反应,改善微循环障碍及神经功能,提高生活能力,较安全可靠。
Objective To analyze the effects of compound troxerutin and poreine cerebroside injection combined with citicoline sodium injection on nerve function,endothelial growth factor(VEGF),thromboxane A2(TXA2)and matrix metalloproteinase-9(MMP-9)in patients with acute cerebral infarction(ACI).Methods According to random number table method,106 patients with ACI admitted to Zhoukou Central Hospital from July 2020 to January 2023 were divided into reference group(given citicoline sodium injection)and study group(given compound troxerutin and poreine cerebroside injection+citicoline sodium injection),with 53 cases in each group.Both groups were given conventional treatment for 14 days.The efficacy,neurological function[National Institutes of Health Stroke Scale(NIHSS)assessment]score,life ability[Modified Rankin Scale(mRS)assessment]score,microcirculation index(VEGF,TXA2,MMP-9),inflammatory factors[hypersensitive C-reactive protein(hs-CRP),monocyte chemotactic protein]before and after treatment were compared between the two groups 1(MCP-1),interleukin-1β(IL-1β),IL-18 and tyrosine protein kinase 2(JAK2)/transcriptional activator 3(STAT3)signaling pathway protein levels.Results The total effective rate of the study group was 92.45%higher than that of the control group 77.36%(P<0.05).After treatment,NIHSS and mRS Scores in the study group were lower than those in the control group after treatment(P<0.05);VEGF in the study group was higher than that in the reference group,and TXA2 and MMP-9 were lower than that in the reference group(P<0.05);hs-CRP,MCP-1,IL-1βand IL-18 in the study group were lower than those in the control group(P<0.05);JAK2,P-JAK2,STAT3 and P-STAT3 in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions in the study group compared to the reference group(P>0.005).Conclusion Compound troxerutin and poreine cerebroside injection with citicoline sodium injection is effective in the treatment of ACI,reducing inflammation,im
作者
孙涛
SUN Tao(Zhoukou Central Hospital,Zhoukou Henan 466000,China)
出处
《药品评价》
CAS
2023年第9期1156-1160,共5页
Drug Evaluation
关键词
脑梗死
胞磷胆碱
复方曲肽注射液
神经功能
Brain infarction
Citicoline
Compound troxerutin and poreine cerebroside injection
Neural function
