摘要
药物相关肾毒性是住院患者发生急性肾损伤(acute kidney injury,AKI)的一个重要原因,其中抗生素可造成结构性和功能性肾损伤。目前抗生素相关的AKI仍是临床应用中未解决的难题。代谢组学作为近年来发展迅速的技术,最接近人体表型的层面,通过检测机体内代谢物的变化,可直观反映人体的部分生理病理变化。本文综述了近年来抗生素药物相关AKI的代谢组学研究,重点阐述紊乱代谢通路以及潜在生物标志物,并对未来进一步的研究进行展望。
Drug-induced nephrotoxicity remains a common cause of acute kidney injury(AKI)in hospitalized patients.Among common AKI-associated drugs,antibiotics act as a potential contributor to both structural and functional kidney injury.Antibiotic-related AKI has remained a clinical dilemma.Metabolomics has been evolved rapidly in recent years.Metabolites are end-products of the phenotypes,bridging from gene to physiological and pathological changes of human beings.Elaborating on metabolomics of antibiotics associated with AKI,this review focused upon the novel biomarkers of AKI occurrence and disturbed metabolic pathways.
作者
张元元
杨丽
赵立波
李晓娜
Zhang Yuan-yuan;Yang Li;Zhao Li-bo;Li Xiao-na(Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China;Therapeutic Drug Monitoring&Clinical Toxicology Center of Peking University,Beijing 100191,China)
出处
《临床肾脏病杂志》
2023年第12期1023-1027,共5页
Journal Of Clinical Nephrology
基金
国家自然科学基金青年基金资助项目(31901040)。
关键词
抗生素
肾损伤
代谢紊乱
生物标志物
Antibiotics
Kidney injury
Metabolic disturbance
Biomarkers
