摘要
组织工程的一般策略是使用生物支架作为人工基质替代天然细胞外基质(ECM)支持细胞的生存和各项功能,从而形成新的组织.作为一类重要的生物大分子,糖质(glycan)是ECM的主要组分,其所承载的基质和信息功能使其成为一种极有潜力的制备组织工程支架的原材料.与此同时,基于可逆非共价相互作用的水凝胶,因其可以实现对水凝胶时空结构的精确操纵,从而模拟细胞所需的生存环境,促进组织的再生修复,近年来得到了重视和研究.本文从模拟ECM的结构和功能切入,将糖质功能与非共价作用结合起来,介绍多种糖动态超分子水凝胶的设计思路和构筑原理,讨论其在组织工程应用中需要实现的关键性能,并对其在该领域的发展趋势进行展望.
The general strategy of tissue engineering is to use bioactive scaffolds as artificial extracellular matrix(ECM)to support cell survival and functions to repair and regenerate injured tissues.Glycans are the major component of ECM,and the matrix and information properties of glycans make them promising building blocks for fabricating biomaterial scaffolds for tissue engineering.Meanwhile,dynamic hydrogels based on reversible non-covalent interactions have attracted much attention in recent years because they can achieve precise manipulation of the network dynamics of supramolecular hydrogels to simulate the conducive microenvironment required by cells and promote the eventual regeneration of injured tissues.Based on the combination of glycan functions and non-covalent interactions,this review summarizes the design strategies of glycan-based dynamic supramolecular hydrogels inspired by the dynamic structure and functions of ECM and the applications of these hydrogels in the field of tissue engineering.
作者
卞欣雨
高晨迪
边黎明
陈国颂
Xinyu Bian;Chendi Gao;Liming Bian;Guosong Chen(The State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular Science,Fudan University,Shanghai 200433,China;Key Laboratory of Biomedical,Materials and Engineering of the Ministry of Education,South China University of Technology,Guangzhou 510006,China)
出处
《中国科学：化学》
CAS
CSCD
北大核心
2023年第12期2433-2443,共11页
SCIENTIA SINICA Chimica
基金
国家重点研发计划(2022YFB3804401)资助项目。
关键词
糖
超分子
水凝胶
组织工程
细胞外基质
glycan
supramolecular
hydrogel
tissue engineering
extracellular matrix
