摘要
作为一种新发现的程序性细胞死亡方式,铁死亡与全身多种疾病发生发展密切相关,如消化系统肿瘤、缺血再灌注损伤、骨关节病等。近年来,铁死亡已经成为许多领域的研究热点,为相关疾病防治提供了新思路。其中骨关节病的关节软骨、软骨下骨、滑膜组织等结构病变均被发现与铁超载以及氧化应激有关,提示抑制关节组织细胞铁死亡可能对阻止骨关节病发生发展有积极作用。本文以铁死亡和骨关节病为主题,结合最新研究发现,综述人体铁代谢及细胞铁死亡相关机制的研究动态,分析铁死亡对骨关节病发生发展的影响,并为骨关节病的药物治疗提出新思路。
Ferroptosis,a newly-discovered mode of programmed cell death,is closely associated with the development of various diseases throughout the human body,such as tumors of the digestive system,ischemia-reperfusion injury,osteoarthropathy,etc.Therefore,ferroptosis has become a hot research topic in many fields of study in recent years,providing new ideas for the prevention and treatment of relevant diseases.Among them,structural lesions in osteoarthropathies involving articular cartilage,subchondral bone,and synovial tissue have been found to be associated with iron overload,as well as oxidative stress,which suggests that inhibition of ferroptosis in relevant joint tissue cells may have a positive effect in halting the development of osteoarthropathy.Herein,focusing on ferroptosis and osteoarthropathy,we summarized the research developments in mechanisms related to iron metabolism and ferroptosis,analyzed the impact of ferroptosis on the pathogenesis and development of osteoarthropathy,and proposed new ideas for medication therapies of osteoarthropathy,taking into account the latest research findings.
作者
安可
周学东
AN Ke;ZHOU Xuedong(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2023年第6期1294-1299,共6页
Journal of Sichuan University(Medical Sciences)
关键词
骨关节病
铁死亡
铁超载
脂质过氧化
氧化应激
综述
Osteoarthropathy
Ferroptosis
Iron overload
Lipid peroxidation
Oxidative stress
Review
