摘要
目的分析血栓通在ST段抬高型急性心肌梗死(ST-elevation myocardial infarction,STEMI)急诊经皮冠状动脉介入术(percutaneous coronary intervention,PCI)术后患者中的应用效果。方法随机选取2021年2月—2023年1月江南大学附属医院急诊接受PCI手术的STEMI患者80例,使用随机数表法分为两组,对照组40例患者术后使用阿托伐他汀治疗,研究组40例在对照组基础上应用血栓通治疗。对两组患者左室射血分数、左室舒张末期内径、左室收缩末期内径、一氧化氮(nitrie oxide,NO)、内皮素(endo thelin,ET)指标,以及心脏不良事件(major adverse cardiovascular events,MACE)与不良反应发生率进行比较。结果治疗4周后,研究组左室射血分数为(61.52±8.02)%高于对照组的(55.63±7.80)%,差异有统计学意义(t=3.330,P<0.05),左室舒张末期内径为(47.05±6.08)mm、左室收缩末期内径为(37.52±5.02)mm低于对照组的(50.65±5.78)、(40.60±6.00)mm,差异有统计学意义(t=2.714、2.490,P<0.05)。治疗4周后,研究组NO指标高于对照组,差异有统计学意义(P<0.05),ET指标低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。随访6个月,研究组MACE发生率为5.00%低于对照组的22.50%,差异有统计学意义(χ^(2)=5.208,P<0.05)。结论血栓通在急诊接受PCI治疗的STEMI患者中具有较为满意的应用效果,可以改善其心功能与内皮功能,降低MACE概率,安全性较为理想。
Objective To analyze the application effect of Xueshuantong in postoperative ST-elevation acute myocardial infarction(STEMI)patients after emergency percutaneous coronary intervention(PCI).Methods A total of 80 patients with STEMI who underwent PCI surgery in the Department of Emergency Medicine of Affiliated Hospital of Jiangnan University from February 2021 to January 2023 were randomly selected and divided into two groups using a random number table method.40 patients in the control group were treated with atorvastatin after surgery,and 40 patients in the study group were treated with Xueshuantong on the basis of the control group.The left ventricular ejection fraction,left ventricular end-diastolic internal diameter,left ventricular end-systolic internal diameter,nitric oxide(NO),endothelin(ET)indexes,as well as the incidence of major adverse cardiovascular events(MACE)and adverse reactions were compared between the two groups.Results The left ventricular ejection fraction was higher in the study group[(61.52±8.02)%]than in the control group[(55.63±7.80)%]after 4 weeks of treatment,the differences were statistically significant(t=3.330,P<0.05).Left ventricular end-diastolic internal diameter was(47.05±6.08)mm and left ventricular end-systolic internal diameter was(37.52±5.02)mm,which were lower compared to control group[(50.65±5.78)mm]and[(40.60±6.00)mm],and the differences were statistically significant(t=2.714,2.490,P<0.05).After 4 weeks of treatment NO index in the study group was higher than in the control group,and the difference was statistically significant(P<0.05),and ET index in the study group was lower than in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).At 6 months of follow-up,the incidence of MACE in the study group was 5.00%lower than 22.50%in the control group,the difference was statistically significant(χ^(2)=5.208,P<0.05).Conclusion Xueshuantong has mo
作者
张冰玉
韩冬
黄铭
张雷
孙炜
ZHANG Bingyu;HAN Dong;HUANG Ming;ZHANG Lei;SUN Wei(Department of Emergency Medicine,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu Province,214122 China)
出处
《中外医疗》
2023年第28期85-89,共5页
China & Foreign Medical Treatment
