摘要
目的:观察连花清瘟颗粒联合奥司他韦治疗急性流行性感冒的有效性及安全性。方法:选择120例急性流行性感冒患者,按照随机数字表法分为观察组和对照组,每组60例。观察组给予连花清瘟颗粒联合磷酸奥司他韦治疗,对照组给予磷酸奥司他韦治疗,两组均连续治疗5天。比较两组治疗后临床疗效、临床症状恢复时间(发热、咳嗽、鼻塞、咽痛及流涕时间)、安全性、中医证候积分及血清炎症因子[血清C反应蛋白(c-reactive protein,CRP)、干扰素(interferon,IFN-γ)、白细胞介素6(interleukin-6,IL-6)、白细胞介素8(interleukin-8,IL-8)]水平。结果:治疗后,两组主症、次症及总积分均低于治疗前,且观察组各项评分均低于对照组(P<0.05)。观察组临床疗效[98.33%(59/60)]高于对照组[86.67%(52/60)](P<0.05)。治疗后,观察组发热、咳嗽、鼻塞、咽痛及流涕缓解时间明显少于对照组(P<0.05)。治疗后,两组CRP、IFN-γ、IL-6、IL-8水平均较治疗前下降(P<0.05),且观察组治疗后上述指标水平低于对照组(P<0.05)。两组在治疗过程中均未见不良反应,且血尿常规及肝肾功能均正常。结论:连花清瘟颗粒联合奥司他韦可有效治疗急性流行性感冒,效果显著,且安全性高。
Objective:To observe the effectiveness and safety of Lianhua Qingwen granules and oseltamivir in the treatment of acute influenza.Methods:A total of 120 patients were chosen,and allocated to the observation group and the control group in light of random number table method with 60 cases in each group.The observation group was treated by Lianhua Qingwen granules and oseltamivir,and the control group by oseltamivir,both groups were treated for five days.To compare clinical effects,the recovery time of clinical symptoms including fever,cough,stuffy nose,sore throat and the duration of runny nose,safety,TCM syndrome integrals and the levels of serum inflammatory factors[CRP,IFN-γ,IL-6 and IL-8]between both groups after the treatment.Results:After the treatment,the scores of main symptoms and secondary symptoms and total scores of both groups were lower than these before treating,and the observation group was lower than the control group in different scores(P<0.05).Clinical effective rate of the observation group was[98.33%(59/60)],higher than[86.67%(52/60)]of the control group(P<0.05).After the treatment,the remission time of fever,cough,stuffy nose,sore throat and the runny nose of the observation group was obviously less than that of the control group(P<0.05).After the treatment,the levels of CRP,IFN-γ,IL-6 and IL-8 of both groups were dropped than these before the treatment(P<0.05),the levels of the above indexes of the observation group were lower than these of the control group(P<0.05).No adverse reaction occurred during therapeutic course in both groups,routine blood and urine,liver and kidney function were normal.Conclusion:Lianhua Qingwen granules and oseltamivir is effective in the treatment of acute influenza with noticeable effects and high safety.
作者
陈新
欧茜
CHEN Xin;OU Qian(General Hospital of PLA Southern Theater Command,Guangzhou 510010,China;Foresea Life Insurance Guangzhou General Hospital,Guangzhou 511300,China)
出处
《西部中医药》
2023年第12期109-112,共4页
Western Journal of Traditional Chinese Medicine
基金
广州市科技计划项目(201509010012)。
