摘要
目的:分析产妇深静脉血栓(DVT)发生危险因素及产前D-二聚体(D-D)水平及产后变化预测DVT的价值。方法:选取2018年5月-2022年5月在我院分娩的孕妇临床资料,将产后发生DVT的66例产妇作为DVT组,产后未发生DVT的128例孕妇作为非DVT组,比较两组产前1d D-D水平、产后1d D-D水平及D-D变化幅度,分析D-D水平及变化幅度对产后DVT的预测价值[受试者工作特征(ROC)曲线以及影响产后发生DVT的危险因素[logistic回归分析。结果:血清D-D水平两组产后均高于产前,DVT组产前D-D(4.24±1.17 mg/L)、产后D-D(9.97±2.40 mg/L)及D-D变化幅度(5.73±1.23 mg/L)均高于非DVT组(3.11±1.03 mg/L、7.92±2.14 mg/L、4.81±1.11 mg/L)(均P<0.05);ROC曲线分析显示,产妇产前D-D水平及产后D-D变化幅度预测产后DVT的曲线下面积(AUC)分别为0.756和0.720、截断值分别为4.15 mg/L和5.24 mg/L;logistic回归分析显示,产前D-D水平≥4.15 mg/L、产后D-D变化幅度≥5.24 mg/L、产后出血量≥1000 ml、久卧坐床、妊娠期高血脂、高血压或高血糖、子痫前期是产妇产后发生DVT的独立危险因素(P<0.05)。结论:产后DVT产妇产前D-D水平显著升高,产前D-D水平升高及产后变化幅度大产后发生DVT的独立危险因素,且对产后DVT的发生有一定临床预测价值。
Objective:To analyre the risk factors of the deep vein thrombosis(DVT)of parturients,and to study the values of the prenatal D dimer(D-D)level and the change of the postpartum D-D level of the parturients for predicting their DVT.Methods:The elinical data of the parturients who had delivered in hospital between May 2018 and May 2022 were selected in this study.Among the parturients.66 cases with posipartum DVT were in study group and 128 cases without DVT were in control group.The D-D level of the parturients in the prenatal 1 day and in the postpartum 1 day,the change amplitude of the D-D level of the parturients were compared between the two groups.The predictive value of the D-D level and its change amplitude of the parturients for their postpartum DVT was analyred by receiver operating characteristic(ROC)curve.The risk factors of the postpartum DVT occurrence of the parturients were ana-lyzed by Logistic reression analysis.Results:The serun D-D level of the parturients in the two group after delivery had incressed significantly.The prenatal D-D level(4.24±1.17 mg/L).the postpartum D-D level(9.97±2.40 mg/L).and the change amplitude of D-D level(5.73±1.23 mg/L)of the parturients in the study group were significantly high-er than those(3.11±1.03 mg/L.7.92±2.14 mm mg/L.and 4.81±1.11 mg/L)of the parturients in the control group(all P<0.05).ROC curve analysis showed that the sarea under curve(AUC)of the prenatal D-D level and the change amplitude of D-D level of the parturients for predicting their postpartum DVT were 0.756 and 0.720.the cutoff value of which were 4.15 mg/L and 5.24 mg/L..Logistic regression analysis showed that the prenatal D-D level≥4.15 mg/L.the change amplitude of postpartum D-D level≥5.24 mg/L,the postpartum haemorrhage amount≥1000 ml,the long lie in bed.and the hyperlipidemia.the hypertension.and the bhypeglycemia during pregnancy.and the preeclampsia of the parturients were all the independent risk factors of their postpartum DVT(P<0.05).Conclusion:The level of the prenatal D-D o
作者
陈巧艳
吴雪丽
陈嘉
CHEN Qiaoyan;WU Xueli;CHEN Jia Wuyi(Courty Maternal and Child Healsh Care Hospilal,Jinhua,Zhejiang Province,321200)
出处
《中国计划生育学杂志》
2023年第12期2947-2951,共5页
Chinese Journal of Family Planning
关键词
产后深静脉血栓
D-二聚体
预测
影响因素
Postpartum deep vein thrombosis
D dimer
Prediction
Influence factor
