摘要
目的:采用比索洛尔联合单硝酸异山梨酯治疗心肌缺血患者,以期探究心肌缺血安全有效的治疗方案,提高总体效果。方法:纳入2019年1月—2021年1月在九江学院第二附属医院接受诊治的120例心肌缺血患者进行研究,采用完全随机分组法分为观察组和对照组,各60例。两组入院后均行一般治疗,在此基础上对照组采用比索洛尔联合硝酸甘油治疗,观察组采用比索洛尔联合单硝酸异山梨酯治疗,两组出院后仍居家治疗。治疗3个月时,评估两组左心室功能[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]、血管内皮功能[一氧化氮(NO)、内皮素-1(ET-1)],记录两组治疗前及治疗结束后1个月的症状发作频次;治疗期间观察两组不良反应。结果:治疗3个月,观察组LVEF高于对照组,LVEDD、LVESD均低于对照组,观察组血清NO高于对照组,血清ET-1水平低于对照组(P<0.05)。治疗期间两组不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗结束后1个月,两组心绞痛发作次数较治疗前均减少,观察组少于对照组,心绞痛发作持续时间相较于治疗前均缩短,观察组短于对照组(P<0.05)。结论:心肌缺血患者采用比索洛尔联合单硝酸异山梨酯治疗后左心室功能得以改善,心绞痛发作频次得以控制,还可改善血管内皮功能,且具有一定安全性。
Objective:To use Bisoprolol combined with Isosorbide Mononitrate in the treatment of patients with myocardial ischemia,in order to explore a safe and effective treatment scheme for myocardial ischemia and improve the overall effect.Method:A total of 120 patients with myocardial ischemia who were diagnosed and treated in the Second Affiliated Hospital of Jiujiang University from January 2019 to January 2021 were included in the study.A complete random grouping method was used to divide patients into the observation group and the control group,with 60 cases in each group.Both groups received general treatment after admission,on this basis,the control group was treated with Bisoprolol complicated with Nitroglycerin,and the observation group was treated with Bisoprolol complicated with Isosorbide Mononitrate,both groups were still treated at home after discharge.At 3 months of treatment,left ventricular function[left ventricular ejection fraction(LVEF),left ventricular enddiastolic diameter(LVEDD),left ventricular endsystolic diameter(LVESD)]and vascular endothelial function[nitric oxide(NO),endothelin-1(ET-1)]of the two groups were evaluated.The frequency of symptoms before treatment and 1 month after treatment was recorded in the two groups;the adverse reactions of the two groups were observed during the treatment.Result:At 3 months of treatment,the LVEF in the observation group was higher than that in the control group,LVEDD and LVESD were low than those in the control group,the serum NO in the observation group was higher than that in the control group,and the serum ET-1 level was lower than that in the control group(P<0.05).There was no statistical significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).1 month after treatment,the frequency of angina pectoris attacks in the two groups were decreased compared with that before treatment,and the observation group was less than the control group,and the duration of angina pectoris attack was shorter than tha
作者
汪明
程彩云
WANG Ming;CHENG Caiyun(The Second Affiliated Hospital of Jiujiang University,Jiujiang 332000,China;不详)
出处
《中国医学创新》
CAS
2023年第34期66-71,共6页
Medical Innovation of China
关键词
心肌缺血
比索洛尔
硝酸甘油
单硝酸异山梨酯
心功能
症状发作频次
Myocardial ischemia
Bisoprolol
Nitroglycerin
Isosorbide Mononitrate
Cardiac function
Frequency of symptom attack
