摘要
目的:探讨不同剂量瑞马唑仑全麻诱导在老年患者手术中的临床价值。方法:选取2020年4月—2021年8月135例接受腹腔镜手术治疗的老年患者作为研究对象,随机分为低剂量组(接受0.3 mg/kg瑞马唑仑全麻诱导,67例)与高剂量组(接受0.4 mg/kg瑞马唑仑全麻诱导,68例);对比两组患者手术不同时间的平均动脉压(MAP)、匹兹堡睡眠质量指数(PSQI)、一氧化氮(NO)、心率(HR)、肾上腺皮质激素(ACTH)、简易精神状态评价量表(MMSE)、血氧饱和度(SaO_(2))情况。结果:诱导30 min后低剂量组的SaO_(2)、MAP高于高剂量组,HR低于高剂量组,差异有统计学意义(t=6.321、3.125、3.450,P<0.05);术后2 d低剂量组的ACTH、NO、PSQI评分低于高剂量组,MMSE评分高于高剂量组,差异有统计学意义(t=3.989、5.319、6.498、10.275,P<0.05)。结论:0.3 mg/kg剂量的瑞马唑仑在老年患者手术中全身麻醉诱导效果优于0.4 mg/kg,患者术中血液动力学稳定性更好且手术应激更小。
Objective:To investigate the clinical value of induction of general anesthesia with different doses of rimazolam in elderly patients undergoing surgery.Methods:135 elderly patients treated with laparoscopic surgery from April 2020 to August 2021 were randomly selected and divided into a low-dose group(receiving 0.3 mg/kg rimazolam for general anesthesia induction,67 patients)and a high-dose group(receiving 0.4 mg/kg rimazolam for general anesthesia induction,68 patients).The mean arterial pressure(MAP),Pittsburgh Sleep Quality Index(PSQI),nitric oxide(NO),heart rate(HR),adrenocorticotropic hormone(ACTH),Simple Mental State Evaluation Scale(MMSE),and oxygen saturation(SaO_(2))at different times of the procedure were compared.Results:After 30 min of induction,SaO_(2) and MAP were higher in the low-dose group than in the high-dose group,and HR was lower than in the high-dose group,with statistically significant differences(t=6.321,3.125,3.450,P<0.05).ACTH,NO,and PSQI scores were lower in the low-dose group than in the high-dose group and MMSE scores were higher than in the high-dose group at 2 d postoperatively,with statistically significant differences(t=3.989,5.319,6.498,10.275,P<0.05).Conclusion:A dose of 0.3 mg/kg of rimazolam induced general anesthesia better than 0.4 mg/kg in elderly patients during surgery,with better intraoperative hemodynamic stability and less surgical stress.
作者
王华彩
徐国兴
Wang Huacai;Xu Guoxing(Department of Surgery,Department of Anesthesia and Perioperative Medicine,The First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan,473000,China)
出处
《黑龙江医学》
2023年第23期2847-2850,共4页
Heilongjiang Medical Journal
基金
河南省医学科技攻关项目(201800265)。
关键词
全身麻醉
麻醉诱导
腹腔镜手术
血液动力学
General anesthesia
Anesthesia induction
Laparoscopic surgery
Hemodynamics
