摘要
目的研究地诺前列酮栓(商品名:欣普贝生)、宫颈双球囊、缩宫素对延期妊娠患者的引产效果。方法135例延期妊娠患者,根据干预方式不同分为甲组、乙组、丙组,每组45例。甲组采用缩宫素进行引产,乙组实施宫颈双球囊进行引产,丙组实施欣普贝生进行引产。比较三组宫颈成熟度评分、引产成功率、临产时间、用药费用、总产程时间、分娩方式及母婴结局。结果用药后,乙组和丙组宫颈成熟度评分分别为(8.45±0.37)、(9.39±0.51)分,均高于甲组的(6.70±0.45)分,差异有统计学意义(P<0.05);丙组宫颈成熟度评分高于乙组,差异有统计学意义(P<0.05)。乙组和丙组引产成功率分别为80.00%、95.56%,均高于甲组的55.56%,差异有统计学意义(P<0.05);丙组引产成功率高于乙组,差异有统计学意义(P<0.05)。乙组和丙组临产时间与总产程时间分别为(8.05±1.23)、(8.92±1.48)h和(5.72±1.06)、(7.09±1.20)h,均短于甲组的(11.68±1.49)、(10.84±1.91)h,用药费用(525.60±91.30)元和(385.90±88.40)元高于甲组的(125.20±80.07)元,差异有统计学意义(P<0.05);丙组临产时间与总产程时间均短于乙组,用药费用低于乙组,差异有统计学意义(P<0.05)。乙组和丙组阴道分娩率分别为93.33%、95.56%,均高于甲组的73.33%,差异有统计学意义(P<0.05);丙组和乙组的阴道分娩率比较,差异无统计学意义(P>0.05)。乙组和丙组产后出血率、围生儿不良结局发生率分别为4.44%、6.67%和2.22%、2.22%,均低于甲组的20.00%、22.22%,差异有统计学意义(P<0.05);丙组和乙组产后出血率、围生儿不良结局发生率比较,差异无统计学意义(P>0.05)。结论针对延期妊娠患者引产,欣普贝生、宫颈双球囊的效果与安全性均比缩宫素更高,欣普贝生对促进宫颈成熟度的效果更好,有助于缩短产程时间,价格较宫颈双球囊更低,因此更适合推广在基础医疗机构中。
Objective To study the effect of labor induction of dinoprostone suppositories,cervical double balloon and oxytocin in patients with prolonged pregnancy.Methods A total of 135 patients with prolonged pregnancy were divided into group A,group B and group C according to different intervention methods,with 45 cases in each group.Group A was induced by oxytocin,group B was induced by cervical double balloon,and group C was induced dinoprostone suppositories.Comparison was made on cervical maturity score,success rate of labor induction,labor time,medication cost,total duration of labor,delivery mode and maternal and infant outcomes among the three groups.Results After treatment,the cervical maturity scores in group B and group C were(8.45±0.37)and(9.39±0.51)points,which were higher than that of(6.70±0.45)points in group A,and the difference was statistically significant(P<0.05).The cervical maturity score of group C was higher than that of group B,and the difference was statistically significant(P<0.05).The success rates of labor induction in group B and group C were 80.00%and 95.56%,which were higher than that of 55.56%in group A,and the difference was statistically significant(P<0.05).The success rate of labor induction in group C was higher than that in group B,and the difference was statistically significant(P<0.05).The labor time and total duration of labor in group B and group C were(8.05±1.23),(8.92±1.48)h and(5.72±1.06),(7.09±1.20)h,which were shorter than those of(11.68±1.49)and(10.84±1.91)h in group A;the medication cost in group B and group C were(525.60±91.30)and(385.90±88.40)yuan,which were higher than that of(125.20±80.07)yuan in group A;the differences were statistically significant(P<0.05).The labor time and total duration of labor in group C were shorter than those in group B,and the medication cost was lower than that in group B.The differences were statistically significant(P<0.05).The vaginal delivery rates in group B and group C were 93.33%and 95.56%,which were higher than that of 73.3
作者
林荔
曾丽娜
张艳
LIN Li;ZENG Li-na;ZHANG Yan(Prenatal Diagnosis Center,Affiliated Hospital of Putian University,Putian 351100,China)
出处
《中国现代药物应用》
2023年第22期22-27,共6页
Chinese Journal of Modern Drug Application
关键词
延期妊娠
引产
地诺前列酮栓
宫颈双球囊
缩宫素
Prolonged pregnancy
Induced abortion
Dinoprostone suppositories
Cervical double balloon
Oxytocin
