摘要
目的 分析竖脊肌平面阻滞对肺癌患者胸腔镜手术后肿瘤标志物及认知功能的影响。方法 选取2018年1月至2023年3月盐城市第三人民医院胸腔镜手术后的肺癌患者122例,根据单双数数字标记法随机将其分为复合组和常规组,每组各61例。常规组给予常规全身麻醉,复合组进行竖脊肌平面阻滞复合全身麻醉,比较两组术后疼痛、肿瘤标志物及认知功能情况等。结果 术后12、24、48 h复合组视觉模拟评分(VAS)显著低于常规组,差异有统计学意义(t=8.661,9.257,8.863,P<0.05);术后48 h复合组糖抗原199(CA199)、糖抗原125(CA125)、癌胚抗原(CEA)等指标水平均低于常规组,差异有统计学意义(t=13.507,2.301,10.016,P<0.05);术后1、12、24 h复合组简易智力状态检查(MMSE)评分均显著高于常规组,差异有统计学意义(t=7.255,6.726,7.241,P<0.05)。结论 竖脊肌平面阻滞应用于肺癌患者胸腔镜手术中,不仅可有效改善机体疼痛程度并降低肿瘤标志物表达,同时还可提高患者术后认知功能情况,具有较高的临床价值,值得应用推广。
Objective To analyze the effects of erector ridge plane block on tumor markers and cognitive function in patients with lung cancer after thoracoscopic surgery.Methods A total of 122 patients with lung cancer who underwent thoracoscopic surgery in the Third People's Hospital of China from January 2018 to March 2023 were selected and randomly divided into the compound group and the conventional group according to odd-even number labeling method,with 61 cases in each group.The conventional group was given conventional general anesthesia,and the compound group was given erector spinus plane block combined general anesthesia.Postoperative pain,tumor markers and cognitive function were compared between the two groups.Results Visual analogue score(VAS)of the compound group was significantly lower than that of the conventional group at 12,24 and 48 hours after operation,with statistical significance(t=8.661,9.257,8.863,P<0.05).The levels of carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)in the compound group were lower than those in the conventional group 48 hours after operation,and the differences were statistically significant(t=13.507,2.301,10.016;P<0.05).The MMSE scores of the compound group were significantly higher than those of the conventional group 1,12 and 24 hours after operation,with statistical significance(t=7.255,6.726,7.241,P<0.05).Conclusion The application of erector ridge muscle plane block in thoracoscopic surgery for lung cancer patients can not only effectively improve the degree of pain and reduce the expression of tumor markers,but also improve the postoperative cognitive function of patients,which has high clinical value and is worthy of application and promotion.
作者
纪月珑
于广东
李向南
王中苏
邓龙生
JI Yueong;YU Guangdong;LI Xiangnan;WANG Zhongsu;DENG Longsheng(Department of Anesthesiology,the Third People's Hospital of Yancheng,Yancheng,Jiangsu,China,224000)
出处
《分子诊断与治疗杂志》
2023年第10期1707-1710,共4页
Journal of Molecular Diagnostics and Therapy
基金
江苏省老年健康科研项目(LKZ2022002)。
关键词
竖脊肌平面阻滞
肺癌
胸腔镜手术
肿瘤标志物
Erector spinalis plane block
Lung cancer
Thoracoscopic surgery
Tumor marker
