摘要
目的探讨口腔鳞状细胞癌(OSCC)细胞毒性T淋巴细胞相关抗原4(CTLA4)、生长因子受体结合蛋白2协同结合蛋白2(Gab2)表达与患者临床病理特征及预后的关系。方法抽取2018年7月至2020年7月河南大学第一附属医院收治的62例OSCC患者作为研究对象,统计CTLA4、Gab2在OSCC癌组织及癌旁组织的表达情况,应用χ^(2)检验分析CTLA4、Gab2表达阳性者或阴性者临床病理特征及预后情况。结果OSCC癌组织中CTLA4阳性表达率(74.19%,46/62)、Gab2阳性表达率(70.97%,44/62)高于癌旁组织(33.87%,21/62;40.32%,25/62),P<0.05。TNM分期Ⅲ~Ⅳ期、中低分化程度、有淋巴结转移者CTLA4阳性表达率及Gab2阳性表达率,分别高于TNM分期Ⅰ~Ⅱ期、高分化程度、无淋巴结转移者(P<0.05)。62例OSCC患者出院后连续随访3年,23例患者存活,总生存率为37.10%(23/62)。CTLA4阴性者3年总生存率高于阳性者,Gab2阴性者3年总生存率高于阳性者(P<0.05)。结论OSCC患者癌组织中CTLA4、Gab2阳性表达率高,其与TNM分期、分化程度、淋巴结转移及3年生存率相关,CTLA4、Gab2表达阳性对OSCC患者病情判断及预后评估有重要参考价值。
ObjectiveTo investigate the correlation of expression of cytotoxic T lymphocyte-associated antigen 4(CTLA4)and growth factor receptor-bound protein 2(Gab2)in oral squamous cell carcinoma(OSCC)with clinicopathologic feature and prognosis.MethodsA total of 62 patients with OSCC admitted to the First Affiliated Hospital of Henan University from July 2018 to July 2020 were selected as research subjects.The expressions of CTLA4 and Gab2 in cancer tissues and adjacent tissues of OSCC were counted,and theχ^(2)test was used to analyze the clinicopathologic feature and prognosis of patients with positive or negative expression of CTLA4 and Gab2.ResultsThe positive expression rate of CTLA4(74.19%,46/62)and Gab2(70.97%,44/62)in OSCC cancer tissue were higher than those in adjacent tissue(33.87%,21/62;40.32%,25/62),P<0.05.The positive expression rate of CTLA4 and Gab2 in patients with TNM stageⅢtoⅣ,moderate to low differentiation,and lymph node metastasis were respectively higher than those in patients with TNM stageⅠtoⅡ,with high degree of differentiation,and no lymph node metastasis,correspondingly(P<0.05).Sixty-two patients with OSCC were followed up continuously for 3 years after discharge,and 23 patients survived,with an overall survival rate of 37.10%(23/62).The 3-year overall survival rate of CTLA4-negative patients was higher than that of CTLA4-positive patients,and the 3-year overall survival rate of Gab2-negative patients was higher than that of Gab2-positive patients(P<0.05).ConclusionsThe positive expression rate of CTLA4 and Gab2 in cancer tissues of OSCC patients is high,which is related to TNM stage,degree of differentiation,lymph node metastasis and 3-year survival rate.The positive expression of CTLA4 and Gab2 provide important references for the evaluation of condition and prognosis of OSCC patients.
作者
苑艺芳
杨中锐
千一
任春富
王金
张婧
厉祖博
Yuan Yifang;Yang Zhongrui;Qian Yi;Ren Chunfu;Wang Jin;Zhang Jing;Li Zubo(Department of Stomatology,the First Affiliated Hospital of Henan University,Kaifeng 475000,China)
出处
《中国实用医刊》
2023年第20期1-4,共4页
Chinese Journal of Practical Medicine
基金
河南省教育厅科学技术研究项目(21A320005)。
