摘要
目的以桂枝茯苓胶囊(Guizhi Fuling Capsules,GFC)和天舒胶囊(Tianshu Capsule,TC)为研究对象,将近红外光谱(near-infrared spectroscopy,NIRS)技术与机器学习算法结合,建立快速检测2种制剂中间体水分的方法。方法采集GFC总混颗粒和TC总混颗粒的NIRS,考察不同的预处理方法、变量筛选方法及算法对模型的影响,筛选最佳建模条件,并对2种中间体建立1个水分NIRS通用定量模型。结果对同一中间体建立定量模型时,广义路径追踪(generalized path seeker,GPS)算法均优于偏最小二乘(partial least square,PLS)算法;GPS通用模型与PLS通用模型相比,预测性能更高,验证集相对偏差(relative standard errors of prediction,RSEP)由3.17%降至3.03%,性能偏差比(ratio of performance to deviation,RPD)由4.83升至5.05,可用于水分的预测,且与独立模型的预测性能相差不大。结论GPS算法结合NIRS技术建立的通用定量模型,可快速、准确地检测2种制剂中间体的水分。
Objective Taking Guizhi Fuling Capsules(GFC,桂枝茯苓胶囊)and Tianshu Capsules(TC,天舒胶囊)as research objects,a rapid method for detecting the moisture content of two preparation intermediates was established by combining near-infrared spectroscopy(NIRS)technology with machine learning algorithms.Methods The NIRS of GFC total mixed particles and TC total mixed particles were collected.The effects of different preprocessing methods,variable screening methods and algorithms on the model were investigated.The optimal modeling conditions were selected to establish a universal NIRS quantitative model for moisture content of two intermediates.Results The generalized path seeker(GPS)algorithm wassuperior to the partial least squares(PLS)algorithm in establishing quantitative models for the same intermediate.Compared with the PLS universal model,the GPS universal model had higher predictive performance,with the relative standard errors of prediction(RSEP)decreasing from 3.17% to 3.03%,and the ratio of performance to deviation(RPD)increasing from 4.83 to 5.05.The GPS universal model could be used to predict the moisture content of intermediates,and there was little difference inprediction accuracy between GPS and that of the independent models.Conclusion The universal quantitative model established by GPS algorithm combined with NIRS technology could quickly and accurately determine the moisture content of two preparation intermediates.
作者
张永超
徐芳芳
李执栋
李秀梅
吴云
刘洪波
王振中
张欣
ZHANG Yong-chao;XU Fang-fang;LI Zhi-dong;LI Xiu-mei;WU Yun;LIU Hong-bo;WANG Zhen-zhong;ZHANG Xin(National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Lianyungang 222001,China;Jangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第22期7436-7444,共9页
Chinese Traditional and Herbal Drugs
基金
连云港市重大技术攻关“揭榜挂帅”项目:中药口服固体制剂智能化连续制造关键技术研究(CGJBGS2101)。
关键词
桂枝茯苓胶囊
天舒胶囊
中间体
广义路径追踪算法
偏最小二乘算法
近红外光谱
机器学习算法
水分
通用模型
验证集相对偏差
性能偏差比
Guizhi Fuling Capsules
Tianshu Capsules
intermediate
generalized path seeker
partial least square
near infrared spectrum
machine learning algorithms
moisture
universal model
relative standard errors of prediction
ratio of performance to deviation
