摘要
重症肌无力是一种自身免疫性疾病,通常由针对神经肌肉接头处的乙酰胆碱受体的抗体介导,其常见的治疗有胆碱酯酶抑制剂,例如溴吡斯的明。该药物在治疗过程中出现心血管事件较少见,但在临床中早期识别病情变化并警惕重症肌无力患者可能出现的心血管事件非常重要。因此,我们报道重症肌无力老年女性患者继发于抗胆碱酯酶治疗导致急性心肌梗死并发心源性猝死的病例,并基于此病例对发生心血管不良事件的可能原因进行讨论。
Myasthenia gravis is an autoimmune disease,which is usually mediated by antibodies to acetylcholine receptors at the neuromuscular junction.It is commonly treated with cholinesterase inhibitors such as pyridostigmine bromide.Although cardiovascular events with the drug are rare,it is very important to early recognize disease changes and be alert to potential cardiovascular events in patients with myasthenia gravis.Therefore,we report a case of an elderly female patient with myasthenia gravis developing acute myocardial infarction and then sudden cardiac death following anticholinesterase therapy,and discuss the possible causes of adverse cardiovascular events based on this case.
作者
周丽枝
胡云
周礼鑫
童理
杨剑文
ZHOU Lizhi;HU Yun;ZHOU Lixin(The First Affiliated Hospital of Hunan Normal University,Changsha 410005,China)
出处
《中风与神经疾病杂志》
CAS
2023年第11期1048-1050,共3页
Journal of Apoplexy and Nervous Diseases
关键词
重症肌无力
急性心肌梗死
溴吡斯的明
胆碱酯酶抑制剂
Myasthenia gravis
Myocardial infarction
Pyridostigmine bromide
Cholinesterase inhibitor
