摘要
蛋白翻译是细胞生命活动最重要的事件之一.蛋白翻译控制使细胞能够迅速和动态地适应各种刺激,其功能的紊乱将导致疾病的发生.因此,解析蛋白翻译机器及其与疾病发生的联系,是生命科学领域的重要课题.非编码RNA(non-coding RNA,ncRNA)的发现被认为是近年来生物学的一个重大突破,其广泛参与细胞生命活动调控,为深入解析蛋白翻译机器及其与疾病发生的紧密联系带来了机遇.本文系统综述了ncRNA调控蛋白翻译与疾病发生的最新进展.分别从rRNA生成加工与核糖体组装、蛋白翻译起始与延伸、非经典翻译调控等蛋白的全景过程,重点回顾了近年来,新型ncRNA调控蛋白翻译在疾病发生发展中的功能,以及作为基于蛋白翻译的新型靶点和治疗策略.从一个新的维度探讨ncRNA参与蛋白翻译机器精密过程,为基于蛋白翻译控制过程治疗疾病提供新的视角和思路.
Protein translation is one of the most important events in cell fates.Protein translation control enables cells to rapidly and dynamically adapt to various stimuli.The disturbance of protein translation will lead to disease occurrence.Therefore,comprehensive understanding of protein translation machinery and its links to disease occurrence is an important issue in the field of life science.In recent years,the discovery of non-coding RNA(ncRNA)is regarded as a significant breakthrough in biology.ncRNA,widely involved in the regulation of cell processes,renders an opportunity for further insight into the protein translation machinery and its close relationship with disease.This paper systematically reviews the recent progress in the function of novel ncRNA upon protein translation and the pathogenesis of diseases.We present a new perspective that ncRNA controls of protein translation,from rRNA production and ribosome assembly,protein translation initiation and extension to non-classical translation regulation.We further summarize the functions of novel ncRNA-regulated protein translation in disease progresses,as well as the application of it as novel targets and therapeutic strategies.In conclusion,novel ncRNAs enable us to understand the precision process of protein translation machines in a new dimension,providing new ideas for the treatment of malignant diseases based on protein translation control processes.
作者
王文涛
陈月琴
WANG WenTao;CHEN YueQin(Guangdong Province Key Laboratory of Pharmaceutical Functional Genes,MOE Key Laboratory of Gene Function and Regulation,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2023年第11期1527-1545,共19页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2022YFA1300020)
广东省杰出青年基金(批准号:2021B1515020002和2019JC05N394004)
中山大学中央高校基本科研业务费-青年拔尖人才培育项目(批准号:231gbj010)资助。
关键词
非编码RNA
蛋白翻译
微肽
疾病发生
non-coding RNA
protein translation
micropeptide
disease occurrence
