摘要
目的:探究超声引导下腰方肌阻滞对结直肠癌手术患者疼痛及认知的影响。方法:选取2019年12月—2022年12月福州市长乐区医院收治的80例结直肠癌手术患者。根据随机数表法将其分为对照组及观察组,各40例。对照组给予常规全身麻醉,观察组在对照组基础上给予超声引导下腰方肌阻滞。比较两组术前、术后1 d、2 d、3 d的疼痛情况,术前、术后1 d、2 d、3 d疼痛介质水平,术后1 d、7 d、14 d的认知功能,术前、术后1 d、7 d、14 d白细胞介素-6(IL-6)及中枢神经特异性蛋白(S100-β)水平。结果:术后1 d、2 d、3 d,观察组视觉模拟评分法(VAS)评分分布均显著优于对照组,差异有统计学意义(P<0.05)。术后1 d、2 d、3 d,观察组前列腺素E_(2)(PGE_(2))及P物质(SP)水平均显著低于对照组,差异有统计学意义(P<0.05)。术后1 d、7 d、14 d,观察组认知功能障碍发生率均显著低于对照组,差异有统计学意义(P<0.05)。术后1 d、7 d、14 d,观察组IL-6、S100-β水平均显著低于对照组,差异有统计学意义(P<0.05)。结论:超声引导下腰方肌阻滞可有效改善结直肠癌手术患者疼痛状态及认知状态。
Objective:To investigate the influence of quadratus lumborum block guided by ultrasound on pain and cognitive of patients undergoing colorectal cancer surgery.Method:A total of 80 patients undergoing colorectal cancer surgery treated in Fuzhou Changle District Hospital from December 2019 to December 2022 were selected.They were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was given routine general anesthesia,and the observation group was given quadratus lumborum block guided by ultrasound on the basis of control group.The pain status before surgery,1 d,2 d and 3 d after surgery,pain mediators level before surgery,1 d,2 d and 3 d after surgery,cognitive function 1 d,7 d and 14 d after surgery,interleukin-6(IL-6)and central nervous system specific proteins(S100-β)level before surgery,1 d,7 d and 14 d after surgery of the two groups were compared.Result:At 1 d,2 d and 3 d after surgery,the visual analogue scale(VAS)score distribution of the observation group were significantly better than those of the control group,the differences were statistically significant(P<0.05).The levels of prostaglandin E2(PGE2)and substance P(SP)in the observation group were significantly lower than those in the control group at 1 d,2 d and 3 d after surgery,and the differences were statistically significant(P<0.05).The incidence of cognitive dysfunction in the observation group were significantly lower than those in the control group at 1 d,7 d and 14 d after surgery,the differences were statistically significant(P<0.05).The levels of IL-6 and S100-βin the observation group were significantly lower than those in the control group at 1 d,7 d and 14 d after surgery,the differences were statistically significant(P<0.05).Conclusion:Quadratus lumborum block guided by ultrasound can effectively improve the pain and cognitive status of patients undergoing colorectal cancer surgery.
作者
陈恩
CHEN En(Fuzhou Changle District Hospital,Fuzhou 350200,China)
出处
《中外医学研究》
2023年第33期10-14,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
超声引导下腰方肌阻滞
结直肠癌
疼痛状态
认知状态
Quadratus lumborum block guided by ultrasound
Colorectal cancer
Pain state
Cognitive state
