摘要
目的:分析肿瘤标志物癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原242(CA242)及糖类抗原724(CA724)联合检测早期胃癌的诊断价值。方法:选取2021年6月—2023年6月在福建医科大学肿瘤临床医学院收治的疑似早期胃癌患者56例作为观察组,另选取同期本院收治的良性胃病患者40例作为对照组,对比两组患者CEA、CA199、CA242及CA724的水平,并分析四项单独检测及联合检测的诊断价值。结果:观察组CEA、CA199、CA242及CA724水平均显著高于对照组,差异有统计学意义(P<0.05)。观察组56例疑似早期胃癌患者中,阳性48例,其中乳头状腺癌25例,管状腺癌23例;阴性8例,其中胃溃疡5例,慢性胃炎3例。CEA、CA199、CA242及CA724联合检测的敏感度为93.75%,准确率为92.86%,均高于4项单独检测的敏感度和准确率,差异有统计学意义(P<0.05),联合检测的特异度和4项单独检测的特异度比较,差异无统计学意义(P>0.05)。结论:肿瘤标志物CEA、CA199、CA242及CA724联合检测早期胃癌的诊断价值较高,显著优于各项单独检测,可为早期胃癌的快速筛查和诊断提供重要的理论参考。
Objective:To analyse the diagnostic value of combining tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 242(CA242)and carbohydrate antigen 724(CA724)in early gastric cancer.Method:From June 2021 to June 2023,56 suspected early gastric cancer patients admitted to Clinical Oncology School of Fujian Medical University were selected as the observation group.In addition,40 patients with benign stomach diseases admitted to in the same period were selected as the control group.The levels of the tumor markers CEA,CA199,CA242 and CA724 were compared between the two groups,and the diagnostic value of the above four tumor markers were tested alone and in combination was analyzed.Result:The levels of CEA,CA199,CA242 and CA724 in observation group were significantly higher than those in control group,the differences were statistically significant(P<0.05).Among the 56 suspected early gastric cancer patients in the observation group,there were 48 positive cases(25 papillary adenocarcinoma cases,23 tubular adenocarcinoma cases)and 8 negative cases(5 gastric ulcers cases,3 chronic gastritis cases).The results showed that the sensitivity and accuracy of the combined detection of CEA,CA199,CA242 and CA724 were 93.75%and 92.86%,which were higher than the sensitivity and accuracy of the four separate tests,and the differences were statistically significant(P<0.05).There was no significant difference between the specificity of the combined test and that of the four separate tests(P>0.05).Conclusion:The combined detection of tumor markers CEA,CA199,CA242 and CA724 has high diagnostic value,which is significantly superior to each single detection,and can provide an important theoretical reference for the rapid screening and diagnosis of early gastric cancer.
作者
周旭升
林青
肖燕萍
ZHOU Xusheng;LIN Qing;XIAO Yanping(Clinical Oncology School of Fujian Medical University,Fuzhou 350001,China)
出处
《中外医学研究》
2023年第31期62-65,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
2022年度福建省中青年教师教育科研项目(JAT220119)。
