摘要
水凝胶是一类亲水但不溶于水的三维网络结构聚合物,通常具有高含水量、良好的生物相容性以及较强的渗透能力。因水凝胶与生物组织具有高度的相似性,广泛应用于组织工程、药物输送、细胞培养等生物医学领域。然而,传统的水凝胶通常表现出机械强度低、易损伤、使用寿命短等局限。近年来,随着分子设计和合成技术的发展,人们开发出了一类具有自动修复损伤能力的自愈水凝胶,极大地弥补了传统水凝胶的缺陷。主要综述了近年来基于动态非共价键和共价键构建自愈水凝胶的研究进展,分别讨论了基于非共价键(包括氢键作用、疏水缔合作用、主客体相互作用和离子相互作用)和共价键(包括硼酸酯键、亚胺键、酰腙键和二硫键)等作用机理构建自愈水凝胶的方法,以及自愈水凝胶在生物医学领域的应用研究进展。最后对自愈水凝胶发展中所面临的挑战和前景作了简要总结,旨在为自愈水凝胶材料的合成及生物医学应用提供一定的参考。
Hydrogels are three-dimensional network polymers,which are hydrophilic but insoluble in water.These materials have high water content,good biocompatibility,and strong permeability.Since the properties of hydrogels are highly similar to biological tissues,hydrogels are widely used in biomedical field,such as tissue engineering,drug delivery,and cell culture.However,traditional hydrogels usually exhibit limitations,such as low mechanical strength,easy to damage,and short service life.In recent years,the self-healing hydrogel with the ability to automatically repair damage has been developed with the improvement of molecular design and synthesis technology,which greatly compensates for the defects of traditional hydrogels.Here,this article mainly reviews the research progress of self-healing hydrogels based on dynamic non-covalent bonds and covalent bonds.The methods of constructing self-healing hydrogels by non-covalent bonds(including hydrogen bonding,hydrophobic association,host-guest interaction and ionic interaction)and covalent bonds(including borate bond,imine bond,acylhydrazone bond and disulfide bond)and the application of self-healing hydrogel in the biomedical field are discussed separately.Finally,we briefly summarize the challenges and prospects of self-healing hydrogels,aimed at providing a certain reference for the synthesis and biomedical applications of self-healing hydrogels.
作者
肖福兵
李红
刘洁
蒙丽君
杜文芳
杨胜园
XIAO Fubing;LI Hong;LIU Jie;MENG Lijun;DU Wenfang;YANG Shengyuan(Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards,School of Public Health,Hengyang Medical School,University of South China,Hengyang 421001,China;College of Biological and Environmental Engineering,Binzhou University,Binzhou 256600,China)
出处
《中国材料进展》
CAS
CSCD
北大核心
2023年第11期855-864,共10页
Materials China
基金
国家自然科学基金项目(21906077,82073604)
湖南省自然科学基金项目(2020JJ5474)
湖南省教育厅优秀青年基金项目(20B508)
中国博士后面上基金项目(2021M690053)
山东省自然科学基金项目(ZR2020QB095)
湖南省重点研发项目(2018SK2029)
湖南省大学生创新创业训练计划项目(S201910555048,S202010555225,S202010555181)
南华大学大学生创新创业训练计划项目(X2019188,2018XJXZ399)。
关键词
聚合物
自愈水凝胶
非共价键
共价键
生物医学
polymers
self-healing hydrogel
non-covalent bond
covalent bond
biomedicine
