摘要
目的探讨血清肿瘤标志物检测在结缔组织病(connective tissue disease,CTD)相关间质性肺疾病(inter-stitial lung disease,ILD)中的应用价值。方法选取2021年1月—2023年4月庆阳市人民医院收治的167例CTD患者为研究对象,依据有无合并ILD分为观察组(CTD-ILD,81例)和对照组(单纯ILD,86例)。采集两组外周静脉血样测定血清肿瘤标志物糖类抗原(carbohydrate antigen,CA)125、CA153、癌胚抗原(carcinoem-bryonic antigen,CEA)、甲胎蛋白(alpha fetoprotein,AFP)、鳞状细胞癌抗原(squamous cell carcinoma antigen,SCC)与神经元特异性烯醇化酶(neuron specific enolase,NSE),比较观察两组上述指标差异,绘制受试者工作特征(ROC)曲线,分析6项指标单一及联合诊断CTD-ILD的临床效能。结果观察组血清CA125(32.96±13.04)U/mL、CA153(20.62±11.30)U/mL、CEA(3.55±1.92)ng/mL、NSE(16.08±5.42)ng/mL,各项指标均高于对照组,差异有统计学意义(t=9.435、6.497、3.002、3.469,P<0.05)。经ROC分析,CA125、CA153、CEA、NSE4项指标的AUC值分别为0.745、0.761、0.834、0.783,均>0.7,对CTD-ILD均有诊断价值,多标志物联合诊断的AUC值为0.942,约登指数为0.731,均高于四项指标单一诊断,差异有统计学意义(P<0.05)。结论CTD-ILD患者血清CA125、CA153、CEA、NSE水平升高,RA-ILD、DM-ILD、pSS-ILD患者血清CA125、CA153、CEA、NSE水平表达存在差异,指标检测对疾病具有诊断价值,多指标联合应用价值更高。
Objective To investigate the application of connective tissue disease(CTD)associated interstitial lung dis-ease(ILD)with connective tissue disease(CTD)associated tumor markers.Methods A total of 167 CTD patients ad-mitted to Qingyang People's Hospital from January 2021 to April 2023 were selected as the study objects,and were di-vided into observation group(CTD-ILD,81 cases)and control group(pure ILD,86 cases)according to whether they had combined ILD.Serum tumor markers carbohydrate antigen(CA)125,CA153,carcinoembryonic antigen(CEA),al-pha fetoprotein,carbohydrate antigen(CA)125 and CA153 were collected from peripheral venous blood samples of 2 groups.AFP,squamous cell carcinoma antigen(SCC)and neuron specific enolase(NSE)were compared and observed.Receiver operating characteristic(ROC)curve was plotted to analyze the clinical efficacy of CTD-ILD in single and combined diagnosis of 6 parameters.Results Serum CA125(32.96±13.04)U/mL,CA153(20.62±11.30)U/mL,CEA(3.55±1.92)ng/mL,NSE(16.08±5.42)ng/mL in observation group were higher than those in control group,the differ-ence was statistically significant(t=9.435,6.497,3.002,3.469,P<0.05).According to ROC analysis,the AUC values of CA125,CA153,CEA and NSEwere 0.745,0.761,0.834 and 0.783,respectively,all of which were>0.7,indicating diagnostic value for CTD-ILD.The AUC value of multi-marker combined diagnosis was 0.942 and the Jorden index was 0.731.All of them were higher than the single diagnosis of the four indexes,and the difference was statistically significant(P<0.05).Conclusion The levels of CA125,CA153,CEA and NSE in serum of CTD-ILD patients were in-creased,and the levels of CA125,CA153,CEA and NSE in serum of RA-ILD,DM-ILD and pSS-ILD patients were different.The detection of these indicators had diagnostic value for the disease,and the combined application of mul-tiple indicators was of higher value.
作者
郑红军
马艺
杨建敏
ZHENG Hongjun;MA Yi;YANG Jianmin(Department of Laboratory,Qingyang People's Hospital,Qingyang,Gansu Province,745000 China)
出处
《系统医学》
2023年第17期14-17,21,共5页
Systems Medicine
关键词
肿瘤标志物
结缔组织病
间质性肺疾病
诊断效能
Tumor markers
Connective tissue disease
Interstitial lung disease
Diagnostic efficiency
