摘要
心脏接受自主神经系统的支配和调控,且交感神经过度激活是心血管疾病进展的关键触发因素。来自下丘脑的心血管自主神经中枢核团可以通过调控外周自主神经系统活性和功能,进而调节心脏生理功能并改善心血管疾病的预后。下丘脑腹内侧核是调控代谢和情绪的重要核团之一,其与下丘脑中的心血管中枢核团及自主神经系统之间存在密切联系,理解三者之间作用关系有助于对脑心交互相关的心血管疾病发病机制的理解,明确下丘脑腹内侧核调控心脏自主神经系统的信号通路和神经递质。现就下丘脑腹内侧核对心脏自主神经系统的调控作用、可能涉及的神经投射和分子信号通路以及调控策略进行综述。
The heart is innervated and regulated by the autonomic nervous system,and excessive activation of the sympathetic nervous system is a key trigger factor for the progression of cardiovascular disease.Cardiovascular autonomic central nuclei in the hypothalamus can regulate cardiac physiological functions and improve the prognosis of cardiovascular diseases by regulating the activity and function of the peripheral autonomic nervous system.Ventromedial hypothalamic nucleus(VMH)is one of the most important nuclei that regulate metabolism and emotion.It is closely related to the cardiovascular central nucleus and the autonomic nervous system in the hypothalamus.Understanding the relationship between the three can help to understand the pathogenesis of cardiovascular diseases related to brain-heart crosstalk,and clarify the signaling pathways and neurotransmitters of the VMH in regulating cardiac autonomic nervous system.This article reviews the regulatory role of VMH on the cardiac autonomic nervous system,the possible involved neural projections,molecular signaling pathways and regulatory strategies.
作者
刘子韩
余锂镭
LIU Zihan;YU Lilei(Department of Cardiology,Renmin Hospital of Wuhan University/Hubei Key Laboratory of Autonomic Nervous System Modulation/Cardiac Autonomic Nervous System Research Center of Wuhan University/Cardiovascular Research Institute,Wuhan University/Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)
出处
《心血管病学进展》
CAS
2023年第11期1015-1018,1056,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(82270532)。
关键词
下丘脑腹内侧核
自主神经系统
心血管系统
下丘脑-垂体-肾上腺轴
Ventromedial hypothalamic nucleus
Autonomic nervous system
Cardiovascular system
Hypothalamus-pituitary-adrenal axis
