摘要
目的比较试管婴儿植入前基因检测(PGT)周期中正常反应人群三种促排卵方案的临床结局,为临床工作提供有价值参考依据。方法选取2020年1月至2022年6月赣州市妇幼保健院收治的78例接受胚胎植入前遗传学检测助孕治疗且卵巢正常反应的女性患者作为研究对象,按照促排卵治疗方案差异,分为甲组(26例)、乙组(26例)、丙组(26例)。甲组采用早卵泡期长效长方案进行促排卵治疗,乙组采用拮抗剂方案进行促排卵治疗,丙组采用高孕激素状态下促排卵方案进行促排卵治疗。比较三组研究对象促性腺激素(Gn)总剂量、Gn天数、促排卵天数、人绒毛膜促性腺激素(HCG)日的内膜厚度、获卵数、第2次减数分裂中期(MⅡ)卵母细胞数、正常受精率、囊胚形成率、优质囊胚率、中重度卵巢过度刺激综合征(OHSS)发生率。结果丙组的HCG日的内膜厚度低于乙组,差异有统计学意义(P<0.05);丙组的Gn天数、促排天数长于乙组,差异有统计学意义(P<0.05);丙组的获卵数和MⅡ卵母细胞数均少于乙组,差异有统计学意义(P<0.05)。丙组、乙组的中重度OHSS发生率低于甲组,差异有统计学意义(P<0.017);丙组、乙组的正常受精率、囊胚形成率、优质胚囊率均高于甲组,差异有统计学意义(P<0.017)。结论PGT周期中正常反应人群,采用高孕激素状态下促排卵方案进行促排卵治疗,可以获得和拮抗剂方案相同的效果。
Objective To compare the clinical outcomes of three ovulation promotion programs in the normal response population in the preimplantation genetic testing(PGT)cycle of test-tube infants,and provide valuable reference for clinical work.Methods A total of 78 female patients with normal ovarian response who received preimplantation genetic testing for pregnancy assistance treatment and were treated in Ganzhou Woman and Children's Health Care Hospital from January 2020 to June 2022 were selected as the study objects.According to the differences in ovulation promotion treatment plans,they were divided into group A(26 cases),group B(26 cases)and group C(26 cases).Group A was treated with a long-acting regimen at the early follicle stage,group B was treated with an antagonist regimen,and group C was treated with an ovulation regimen under high progesterone.The total dose of gonadotropin(Gn),the number of days of Gn,the intimal thickness of human chorionic gonadotropin(HCG)days,the number of oocytes retrieved,the number of oocytes in the second cleavage stage(MⅡ)in the second maturation stage,the normal fertilization rate,the rate of blastocyst formation,the rate of high-quality blastocyst,the incidence of moderate to severe ovarian hyperstimulation syndrome(OHSS),and the amount of ovulation promoting drugs were compared among the three groups.Results The intima thickness of HCG day in group C were lower than those in group B,and the differences were statistically significant(P<0.05).The days of Gn and the days of expulsion promotion in group C were longer than those in group B,and the differences were statistically significant(P<0.05).The number of oocytes retrieved and the number of MⅡoocytes in group C were lower than those in group B,and the differences were statistically significant(P<0.05).The incidence of moderate to severe OHSS in group C and group B was lower than that in group A,and the difference was statistically significant(P<0.017).The normal fertilization rate,blastocyst formation rate and high quality
作者
黄云
HUANG Yun(Department of Reproduction and Genetics,Ganzhou Woman and Children's Health Care Hospital,Jiangxi Province,Ganzhou 341000,China)
出处
《中国当代医药》
CAS
2023年第33期82-85,共4页
China Modern Medicine
基金
江西省卫生计生委科技计划项目(20184069)。
关键词
卵巢功能
胚胎植入前遗传学检测
促排卵
治疗
Ovarian function
Preimplantation genetic testing
Ovulation induction
Treatment
