摘要
巨噬细胞的高度可塑性能够影响肿瘤进展和治疗耐药,目前针对肿瘤相关巨噬细胞(tumor-associated macrophages, TAMs)开发出了多种治疗手段,包括对其进行再极化等。利用化合物阻断巨噬细胞向M2型极化或促进其向M1型极化,利用纳米粒子靶向巨噬细胞递送刺激因子等都是常用的重编程手段。靶向TAMs有望成为一种潜在的抗肿瘤治疗手段。本文主要聚焦于通过对TAMs进行重编程以使其重新获得抗肿瘤能力的免疫疗法。
The high plasticity of macrophages can influence tumor progression and treatment resistance.Various therapeutic approaches have been developed for tumor-associated macrophages(TAMs),including their repolarization.The use of compounds to block the polarization of macrophages to M2 type or to promote their polarization to M1 type,and the use of nanoparticles to target macrophages to deliver stimulatory factors are all commonly used reprogramming methods.Targeting TAMs is expected to be a potential anti-tumor therapy.This paper mainly focused on immunotherapy by reprogramming TAMs to regain anti-tumor ability.
作者
顾佳丹
戴蓓英
GU Jiadan;DAI Beiying(Center for New Drug Safety Evaluation and Research,China Pharmaceutical University,Nanjing 211198,China)
出处
《药学研究》
CAS
2023年第11期909-914,920,共7页
Journal of Pharmaceutical Research
基金
国家自然科学基金项目(面上项目、重点项目、重大项目)(No.82002971)。
关键词
肿瘤相关巨噬细胞
极化
纳米粒子
Tumor-associated macrophages
Polarization
Nanoparticles
