摘要
目的:探讨非小细胞肺癌治疗后早期死亡(<36个月)患者的危险因素。方法:选择2017年1月—2020年1月上饶市人民医院肿瘤放化科收治的非小细胞肺癌患者80例作为研究对象,随访36个月统计死亡率。比较存活患者与死亡患者的性别、年龄、卡氏功能状态(KPS)评分、病理分期、组织分化程度、肿瘤类型、病灶数目、肿瘤大小、预后营养指数(PNI)、查尔森合并症指数(CCI)、吸烟史、治疗方法、胸腔积液、肺部感染、血红蛋白,并采取非条件logistic多因素回归分析治疗后早期死亡的独立危险因素。结果:非小细胞肺癌早期存活患者与早期死亡患者的性别、年龄、肿瘤类型、病灶数目、肿瘤最大直径、治疗方法比较,差异均无统计学意义(P>0.05)。非小细胞肺癌早期死亡患者KPS评分<70分、病理Ⅳ期、组织低分化、PNI<45、CCI≥2分、吸烟史、胸腔积液、伴肺部感染、血红蛋白<90 g/L的占比高于早期存活患者(P<0.05)。KPS评分<70分、病理Ⅳ期、组织低分化、PNI<45分、CCI≥2分、吸烟史、胸腔积液、感染、血红蛋白<90 g/L为非小细胞肺癌治疗后早期死亡的独立危险因素(P<0.05)。结论:功能状况差、病理分期高、组织分化程度低、营养状况差、合并症严重、吸烟史、胸腔积液、肺部感染是导致非小细胞肺癌患者治疗后早期死亡的独立危险因素,应做好针对性干预对策,制订个体化治疗方案来降低死亡风险。
Objective:To investigate the risk factors of early death(<36 months)in patients with nonsmall cell lung cancer after treatment.Method:A total of 80 patients with non-small cell lung cancer admitted to Cancer Radiochemistry Department of Shangrao People's Hospital from January 2017 to January 2020 were selected as the study objects,and the mortality rate was calculated after 36 months of follow-up.Gender,age,karnofsky performance status(KPS)scores,pathological stage,degree of tissue differentiation,tumor type,number of lesions,tumor size,prognostic nutrition index(PNI),Chalson comorbidities index(CCI),smoking history,treatment methods,pleural effusion,pulmonary infection,hemoglobin were compared between the surviving patients and deceased patients,the independent risk factors of early death after treatment were analyzed by unconditioned logistic multivariate regression.Result:There were no significant differences in gender,age,tumor type,number of lesions,maximum tumor diameter and treatment methods between early survival patients and early death patients(P>0.05).The proportion of early non-small cell lung cancer patients with KPS score<70 scores,pathological stageⅣ,low tissue differentiation,PNI<45,CCI≥2 scores,smoking history,accompanied by pleural effusion,pulmonary infection,hemoglobin<90 g/L were higher than those of early survival patients(P<0.05).KPS score<70 scores,pathological stageⅣ,low tissue differentiation,PNI<45,CCI≥2 scores,smoking history,pleural effusion,pulmonary infection,and hemoglobin<90 g/L were independent risk factors for early death after treatment for non-small cell lung cancer(P<0.05).Conclusion:Poor functional status,high pathological stage,low tissue differentiation,poor nutritional status,severe complications,smoking history,pleural effusion,pulmonary infection are independent risk factors for early death of non-small cell lung cancer patients after treatment,targeted intervention strategies should be implemented,personalized treatment plans should be developed to reduce the r
作者
熊志坚
周海峰
郑文
XIONG Zhijian;ZHOU Haifeng;ZHENG Wen(Shangrao Center for Disease Control and Prevention,Jiangxi Province,Shangrao 334000,China;不详)
出处
《中国医学创新》
CAS
2023年第33期162-166,共5页
Medical Innovation of China
关键词
非小细胞肺癌
早期死亡
危险因素
病理分期
胸腔积液
Non-small cell lung cancer
Early death
Risk factors
Pathological stage
Pleural effusion
