摘要
铜蓝蛋白(ceruloplasmin,Cp)是一种含铜的α-2球蛋白,是多铜氧化酶家族的一员,主要分布在人体血浆中。铜蓝蛋白的功能主要包括铜的转运、铁稳态的调节、氧化酶活性、抗氧化活性、急性期反应蛋白等,这些功能在许多疾病的发生发展中都发挥着重要作用。随着科学研究不断进展,铜蓝蛋白在各类肿瘤中的作用也不断被揭示,但对于整体认识尚不充分,本文将综述铜蓝蛋白在肿瘤发生发展中的作用,为后续临床及基础科研提供一定参考。
Ceruloplasmin(Cp)is a copper-containingα-2 globulin,a member of the multicopper oxidase family,which is mainly distributed in human plasma.The functions of Cp mainly include copper transport,iron homeostasis regulation,oxidase activities,antioxidant activities,acute-phase protein,which play an important role in the occurrence and development of many diseases.With the continuous development of scientific research,the roles of Cp in various tumors has been revealed,suggesting its potential clinical value.In this review,the research progress of Cp in tumorigeneses and development in recent years will be reviewed,so as to provide certain reference for subsequent clinical and basic scientific research.
作者
谢奇斌
洪流
杨万里
范阿强
XIE Qibin;HONG Liu;YANG Wanli;FAN Aqiang(Department of Digestive Surgery,Xijing Hospital,Air Force Medical University,Shaanxi Xian 710032,China)
出处
《现代肿瘤医学》
CAS
北大核心
2023年第23期4440-4444,共5页
Journal of Modern Oncology
基金
国家自然科学基金课题(编号:82073210)
肿瘤生物学国家重点实验室(第四军医大学)课题(编号:CBSKL2022ZZ37)。
关键词
铜蓝蛋白
铜转运
氧化应激
肿瘤
ceruloplasmin
copper transportation
oxidative stress
tumor
