摘要
目的分析2019—2021年河源市某医院2130例腹泻患者中分离到的沙门菌,探讨沙门菌的感染情况、血清分型及耐药情况。方法选择2019年1月—2021年12月河源市某医院2130例腹泻患者为研究对象,采集粪便标本进行肠道病原菌分离,对实验室检测收集到的沙门菌进行血清型分型和药物敏感性测试。结果170例沙门菌感染患者中年龄以0~10岁居多,其次为60岁以上老年人群,感染时间以7—9月份为主。分离的沙门菌株共有25个血清型,其中鼠伤寒沙门菌变种、鼠伤寒沙门菌和肠炎沙门菌分别为91株、29株和9株,为优势血清型。选取目前临床上常用的4大类抗生素中的8种进行分析,主要有四环素、萘啶酸、氯霉素、环丙沙星、甲氧苄啶/磺胺甲噁唑、庆大霉素、头孢噻肟、头孢西丁。结果表明,四环素的耐药率最高,约为73.17%;其次为萘啶酸,约为55.29%;头孢噻肟较为敏感,敏感率约为73.17%。结论沙门菌属主要对四环素类、萘啶酸类药物的耐药性较高,临床应进一步加强对腹泻患者沙门菌感染的主动监测。
Objective To conduct an analysis of the infection status,serotypes and antimicrobial resistance of Salmonella isolated from 2130 patients with diarrhea from a hospital in Heyuan City,from 2019 to 2021.Methods This study was carried out in a hospital in Heyuan from January 2019 to December 2021.Participants were a sample of patients with diarrhea,whose fecal samples were collected for intestinal pathogen isolation,and serotype and drug susceptibility tests were conducted for laboratory isolated Salmonella.Results A total of 170 cases were found with Salmonella infection,the majority of whom were 0-10-year-olds,followed by over-60-year-olds,and the infection time was mainly from July to September.A total of 25 serotypes were isolated,of which the Salmonella Typhimurium monophasic variant(91 strains),Salmonella typhimurium(29 strains)and Salmonella enteritidis(9 strains)were predominant serotypes.Eight antibiotics(belonging to four types)commonly used in clinical practice were selected for analysis,including tetracycline,nalidixic acid,chloramphenicol,ciprofloxacin,trimethoprim/sulfamethoxazole,genamicin,cefotaxime and cefoxitin.The tetracycline resistance rate was the highest(about 73.17%),followed by nalidixic acid resistance rate(about 55.29%).The Salmonella was susceptible to cefotaxime,and the susceptibility rate was about 73.17%.Conclusion Salmonella is highly resistant to tetracycline and nalidixic acid drugs.Proactive monitoring of Salmonella infection in diarrhea patients should be further strengthened clinically.
作者
吴曼菊
黄丰光
乐燕红
邱雨舒
WU Man-ju;HUANG Feng-guang;LE Yan-hong;QIU Yu-shu(Department of Microbiology Detection,Heyuan Center for Disease Control and Prevention,Heyuan,Guangdong 517000,China)
出处
《中国卫生工程学》
CAS
2023年第5期613-615,共3页
Chinese Journal of Public Health Engineering
关键词
腹泻
沙门菌
血清分型
药物敏感
耐药
敏感
Diarrhea
Salmonella
Serotypes
Drug susceptibility
Drug resistance
Sensitive
