摘要
目的分析永城地区82例妊娠期甲状腺功能减退症的流行病学调查研究,以期为临床早期制定干预方案提供依据。方法以我院2019年1月至2022年12月收治256例妊娠期妇女为研究对象,根据妊娠期间是否发生甲状腺功能减退症将妊娠期妇女分为发生组(82例)和未发生组(174例)。分析妊娠期甲状腺功能减退症的流行病学特征,收集两组临床资料,比较两组年龄、孕前体重指数(BMI)、孕周、孕次、文化程度、自然流产史、孕期补充叶酸、糖尿病、妊娠期高血压、吸烟或暴露于吸烟环境、甲状腺疾病史、甲状腺过氧化物酶抗体(TPO-Ab)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清胃饥饿素(Ghrelin)、肥胖抑制素(Obestatin)、25羟基维生素D3[25-(OH)D3]水平。Logistic多因素回归模型分析影响发生妊娠期甲状腺功能减退症的因素。结果发生组糖尿病、妊娠期高血压、甲状腺疾病史、TPO-Ab、血清Ghrelin、Obestatin、25-(OH)D3水平与未发生组相比存在显著差异(P<0.05);Logistic回归分析显示,糖尿病、妊娠期高血压、甲状腺疾病史、TPO-Ab阳性、血清Obestatin(>44.99 ng/L)是妊娠期妇女发生甲状腺功能减退症的危险因素,血清Ghrelin(>2045.88 pg/mL)、25-(OH)D3(>46.32 IU/mL)是妊娠期妇女发生甲状腺功能减退症的保护因素(P<0.05)。结论糖尿病、妊娠期高血压、甲状腺疾病史、TPO-Ab阳性、血清Obestatin、Ghrelin、25-(OH)D3均与妊娠期妇女发生甲状腺功能减退症密切相关,为临床早期针对性制定干预措施提供参考,以降低甲状腺功能减退症发生风险。
Objective To analyze the epidemiological investigation of 82 cases of hypothyroidism during pregnancy(hypothyroidism)in XX area,so as to provide evidence for early clinical intervention.Methods A total of 256 pregnant women admitted to our hospital from January 2019 to December 2022 were studied,and the pregnant women were divided into an occurrence group(82 cases)and a non-occurrence group(174 cases)according to whether hypothyroidism occurred during pregnancy.The epidemiological characteristics of hypothyroidism during pregnancy were analyzed and clinical data of the two groups were collected.Age,pre-pregnancy body mass index(BMI),gestational age,gestational age,educational level,history of spontaneous abortion,folic acid supplementation during pregnancy,diabetes mellitus,gestational hypertension,smoking or exposure to smoking,history of thyroid disease,thyroid peroxidase antibody(TPO-Ab),triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(H DL-C),low density lipoprotein cholesterol(LDL-C),serum Ghrelin,Obestatin,25 hydroxyvitamin D3[25-(OH)D3]levels.Logistic multivariate regression model was used to analyze the factors affecting the occurrence of hypothyroidism during pregnancy.Results The levels of diabetes mellitus,gestational hypertension,thyroid disease history,TPO-Ab,serum Ghrelin,Obestatin and 25-(OH)D3 in the developing group were significantly different from those in the non-developing group(P<0.05).Logistic regression analysis showed that diabetes mellitus,gestational hypertension,thyroid disease history,TPO-Ab positive and serum Obestatin(>44.99 ng/L)were risk factors for hypothyroidism in pregnant women.Serum Ghrelin(>2045.88pg/mL)and 25-(OH)D3(>46.32 IU/mL)were protective factors for hypothyroidism in pregnant women(P<0.05).Conclusion Diabetes mellitus,gestational hypertension,thyroid disease history,TPO-Ab positive,serum Obestatin,Ghrelin and 25-(OH)D3 are all closely related to hypothyroidism in pregnant women,which provides reference for formulating targeted intervention
作者
刘天保
陈红
谢洋洋
Liu Tian-bao(Department of Medical Laboratory,Yongmei Group General Hospital,Yongcheng 476600,China)
出处
《牡丹江医学院学报》
2023年第5期96-99,共4页
Journal of Mudanjiang Medical University
