摘要
骨质疏松症(OP)的发病机制是由多种信号通路相互交联共同介导的结果,是一种影响中老年人健康的全身代谢性疾病。随着人口老龄化日益加重,OP的发病率也逐年上升,因其发病率高、治愈难度大、预后差等一系列问题,已被国内外学者广泛研究和报道。目前西医治疗OP的药物主要分为骨吸收抑制剂和骨形成促进剂两大类,虽然疗效可靠,但仍存在患者对该药物的依存性较差、不良反应不可控、费用高昂等不足。然而,近年来随着对中医药研究的不断深入与创新,中医药治疗OP在临床得到普遍认可。诸多学者发现,中医药治疗OP的机制中有丝裂原活化蛋白激酶(MAPK)信号通路的广泛参与,其主要通过促进骨髓间充质干细胞(BMSCs)向成骨细胞(OB)分化、抑制破骨细胞(OC)的分化及提高与成骨相关的因子碱性磷酸酶(ALP)、Runt相关转录因子2(Runx2)、Ⅰ型胶原蛋白(ColⅠ)等表达到来治疗OP。虽然目前对于中医药治通过MAPK通路治疗OP的研究不断深入,但在其分子机制研究等方面仍存在一定的不足。因此,该文综述了MAPK信号通路及关键靶点蛋白因子与OP的关系,以明确MAPK信号通路对OP的重要作用。同时,对中药靶向调控MAPK信号通路来治疗OP作以系统总结,以期为中医药进一步精准治疗OP提供科学依据。
Osteoporosis(OP)is a systemic metabolic disease that affects the health of middle-aged and elderly people by crosslinking multiple signaling pathways.With the increasing aging of the population,the incidence of OP is also increasing year by year.Because of a series of problems such as high incidence,difficulty in treatment,and poor prognosis,it has been widely studied and reported by scholars in China and abroad.At present,the drugs used by western medicine are mainly divided into two categories:Bone resorption inhibitors and bone formation promoters.Although the efficacy is reliable,there are still deficiencies such as poor dependence of patients on the drug,uncontrollable side effects,and high costs.However,in recent years,with the continuous deepening and innovation of traditional Chinese medicine(TCM)research,the treatment of OP by TCM has been widely recognized in clinical practice.Many scholars have found that the mechanism of TCM in the treatment of OP includes the widespread involvement of mitogen-activated protein kinase(MAPK)signaling pathway,which mainly promotes the differentiation of bone marrow mesenchymal stem cells(BMSCs)to osteoblasts(OB),inhibits the differentiation of osteoclasts(OC),and improves the expression of osteogenesis-related factors alkaline phosphatase(ALP),Runt-associated transcription factor 2(Runx2),typeⅠcollagen(ColⅠ)to treat OP.Although the current research on the TCM treatment of OP through the MAPK pathway is deepening,there are still certain deficiencies in the study of its molecular mechanism.Therefore,this paper reviewed the relationship between the MAPK signaling pathway and key target protein factors and OP to clarify the important role of the MAPK signaling pathway in OP.At the same time,the targeted regulation of MAPK signaling pathways by TCM to treat OP was systematically summarized in order to provide a scientific basis for the further accurate treatment of OP in TCM.
作者
姚乾宁
谢兴文
李鼎鹏
李宁
杨浩东
胡紫阳
YAO Qianning;XIE Xingwen;LI Dingpeng;LI Ning;YANG Haodong;HU Ziyang(Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Second Provincial People's Hospital of Gansu,Affiliated Hospital of Northwest Minzu University,Lanzhou 730030,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第24期218-224,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81860864,82160911)。
关键词
骨质疏松症
作用机制
丝裂原活化蛋白激酶(MAPK)信号通路
中医药
osteoporosis
mechanism of action
mitogen-activated protein kinase(MAPK)signaling pathway
traditional Chinese medicine
