摘要
肌少症是一种全身性骨骼肌损失、肌肉力量或体能下降的疾病,在类风湿关节炎(RA)中很常见,已成为RA不可忽视的并发症之一。RA并发肌少症患者表现出更高的疾病活动度、更差的躯体功能、更严重的骨破坏和更高的死亡率。目前关于RA并发肌少症的原因和机制尚未完全明确,可能与炎症反应、脂质沉积、线粒体功能障碍和周围神经损害等密切相关,但尚无有效治疗药物。因此,探索RA并发肌少症的发病机制并寻找干预靶点,对于控制疾病进展和改善患者生活质量具有重要意义。
Sarcopenia is a disease of systemic skeletal muscle loss and decreased muscle strength or physical fitness,which is common in rheumatoid arthritis(RA)and has become one of the non-negligible complications of RA.Patients with RA complicated with sarcopenia exhibit higher disease activity,poorer physical function,more severe bone destruction,and higher mortality.At present,the cause and mechanism of sarcopenia complicating RA have not been fully clarified,which may be closely related to inflammation,lipid deposition,mitochondrial dysfunction and peripheral nerve damage,etc.However,there are no effective therapeutic drugs.Therefore,exploring the pathogenesis of sarcopenia complicating RA and finding intervention targets is of great significance for controlling the disease progression and improving the patients′quality of life.
作者
张丽丽
姜萍
渠源
李慧
考希良
ZHANG Lili;JIANG Ping;QU Yuan;LI Hui;KAO Xiliang(Shandong University of Traditional Chinese Medicine,Jinan 250013,China;Department of Rheumatology and Immunology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)
出处
《医学综述》
CAS
2023年第21期4439-4443,4449,共6页
Medical Recapitulate
基金
国家自然科学基金(82274481,81874449)
齐鲁医派中医学术流派传承项目(鲁卫函〔2022〕93号)。
关键词
类风湿关节炎
肌少症
炎症因子
脂质沉积
Rheumatoid arthritis
Sarcopenia
Inflammatory factor
Lipid deposition
