摘要
目的探讨胃癌患者血清糖类抗原72-4(CA72-4)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)水平与外周血CD4^(+)CD25^(+)调节性T(Treg)细胞比例的相关性和临床意义。方法回顾性分析2020年1月至2022年12月在西安长安医院就诊的胃癌患者68例作为胃癌组,另选取同期体检的健康志愿者50例作为对照组。检测并比较两组患者血清CA72-4、CEA、CA19-9水平及外周血CD4^(+)CD25^(+)Treg细胞比例。比较胃癌组不同临床资料患者的CA72-4、CEA、CA19-9水平及CD4^(+)CD25^(+)Treg细胞比例,采用Pearson相关分析胃癌组CA72-4、CEA、CA19-9水平与CD4^(+)CD25^(+)Treg细胞比例的相关性。结果胃癌组血清CA72-4、CEA、CA19-9水平及外周血CD4^(+)CD25^(+)Treg细胞比例比对照组高,差异均有统计学意义(P<0.05)。胃癌组TNM分期为Ⅲ~Ⅳ期患者的CA72-4、CEA、CA19-9水平及CD4^(+)CD25^(+)Treg细胞比例比Ⅰ~Ⅱ期患者高,高~中分化程度患者CA72-4、CEA、CA19-9水平比低分化程度患者低,淋巴结转移患者的CA72-4、CEA、CA19-9水平及CD4^(+)CD25^(+)Treg细胞比例比淋巴结未转移患者高,差异均有统计学意义(P<0.05)。胃癌组血清CA72-4、CEA、CA19-9水平与CD4^(+)CD25^(+)Treg细胞比例均呈正相关(r=0.587,0.678,0.696,P<0.05)。结论胃癌患者血清CA72-4、CEA、CA19-9水平及外周血CD4^(+)CD25^(+)Treg细胞比例明显升高且存在正相关性,与胃癌的发生、发展及肿瘤浸润转移密切相关;CD4^(+)CD25^(+)Treg细胞比例随肿瘤负荷的变化而变化,对胃癌患者病情评估、监测机体免疫状态及判断预后具有一定临床价值。
Objective To investigate the correlation and clinical significance of serum carbohydrate antigen 72-4(CA72-4),carbohydrate antigen(CEA),carbohydrate antigen 19-9(CA19-9)levels and the proportion of CD4^(+)CD25^(+)regulatory T(Treg)cells in patients with gastric cancer.Methods A total of 68 patients with gastric cancer admitted to Xi'an Chang'an hospital from January 2020 to December 2022 were retrospectively analyzed as the gastric cancer group,and 50 healthy volunteers who underwent physical examination in the same period were selected as the control group.Serum CA72-4,CEA,CA19-9 levels and the proportion of CD4^(+)CD25^(+)Treg cells were detected and compared between the two groups.The levels of CA72-4,CEA,CA19-9 and the proportion of CD4^(+)CD25^(+)Treg cells in different clinical data of patients in gastric cancer group were compared,and Pearson correlation analysis was used to analyze the correlation between the levels of CA72-4,CEA,CA19-9 and the proportion of CD4^(+)CD25^(+)Treg cells in gastric cancer group.Results The levels of serum CA72-4,CEA,CA19-9 and the proportion of CD4^(+)CD25^(+)Treg cells in peripheral blood of patients of the gastric cancer group were higher than those of the control group,and the differences were statistically significant(P<0.05).The levels of CA72-4,CEA,CA19-9 and the proportion of CD4^(+)CD25^(+)Treg cells in patients with TNM stage Ⅲ-Ⅳ in gastric cancer group were higher than those in patients with TNM stage Ⅰ-Ⅱ,and the differences were statistically significant(P<0.05).The levels of CA72-4,CEA,CA19-9 in patients with high to moderate differentiation were lower than those in patients with low differentiation,and the differences were statistically significant(P<0.05).The levels of CA72-4,CEA,CA19-9 and the proportion of CD4^(+)CD25^(+)Treg cells in patients with lymph node metastasis were higher than those in patients without lymph node metastasis,and the differences were statistically significant(P<0.05).The serum levels of CA72-4,CEA and CA19-9 in gastric cancer g
作者
李晓霞
高斌成
郭卉
孙乐
LI Xiaoxia;GAO Bincheng;GUO Hui;SUN Le(Department of Internal Medicine Oncology,Xi'an Chang'an Hospital,Xi'an,Shaanxi 710016,China;Department of Internal Medicine Oncology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China)
出处
《检验医学与临床》
CAS
2023年第23期3472-3476,共5页
Laboratory Medicine and Clinic
