摘要
目的探讨醋酸甲地孕酮+宫腔镜电切术治疗早期子宫内膜癌的临床疗效。方法选取医院2020年11月至2021年11月收治的早期子宫内膜癌患者60例,按奇偶数划分法分为对照组和研究组,各30例。对照组采用宫腔镜电切术治疗,研究组在对照组治疗基础上加用醋酸甲地孕酮,比较两组的临床疗效。结果治疗后,研究组患者的血清肿瘤标志物指标好于对照组(P<0.05);研究组与对照组不良反应发生率无显著差异(16.67%比13.33%,P>0.05);实施跟踪回访,研究组患者的子宫内膜癌复发率、肿瘤转移率分别为6.67%和3.33%,均显著低于对照组的30.00%和20.00%(P<0.05);研究组患者治疗后的炎性因子较治疗前显著下降,且较对照组下降更显著(P<0.05)。结论醋酸甲地孕酮+宫腔镜电切术治疗早期子宫内膜癌,临床疗效较好,可降低患者治疗后的复发率和肿瘤转移率,预后改善作用明显。
Objective To investigate the clinical efficacy of megestrol acetate combined with hysteroscopic electrosurgery in the treatment of early endometrial cancer.Methods A total of 60 patients with early endometrial cancer admitted to the hospital from November 2020 to November 2021 were selected and divided into the control group and the study group according to the odd-even division method,with 30 cases in each group.The control group was treated with hysteroscopic electrosurgery,and the study group was treated with megestrol acetate on the basis of the control group,and the clinical efficacy of the two groups was compared.Results After treatment,the serum tumor marker indexes in the study group were better than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group and the control group(16.67%vs.13.33%,P>0.05).After follow-up,the recurrence of the endometrial cancer and tumor metastasis rates in the study group were 6.67%and 3.33%,which were significantly lower than 30.00%and 20.00%in the control group(P<0.05).Conclusion Megestrol acetate combined with hysteroscopic electrosurgery in the treatment of early endometrial cancer has good clinical efficacy,can reduce the recurrence rate and tumor metastasis after treatment,and improve the prognosis significantly.
作者
吕玲
俞玫君
崔永魁
LYU Ling;YU Meijun;CUI Yongkui(Qingdao Geriatric Hospital,Qingdao,Shandong,China 266000)
出处
《中国药业》
CAS
2023年第S01期33-35,共3页
China Pharmaceuticals
关键词
醋酸甲地孕酮
宫腔镜电切术
早期子宫内膜癌
临床疗效
megestrol acetate
hysteroscopic electrosurgery
early endometrial cancer
clinical efficacy
