摘要
肠道菌群对宿主健康和疾病的影响越来越引起人们的关注.近年来,肠道菌群与癌症之间的机制联系具有可能相关性,包括肠道菌群在胃癌发生、发展和治疗中的作用.肠道菌群失调是胃癌的促成因素之一,目前已有初步共识,但其确切的作用机制尚不完全清楚.并且随着研究的深入,肠道菌群在胃癌治疗中也发挥着重要作用.本文综述了肠道菌群对胃癌的影响,阐述了肠道菌群对胃癌发生发展中的作用,讨论了肠道菌群在致癌或胃癌治疗中的可能作用.旨在为今后的进一步研究提供参考和思路.
The impact of the gut microbiota on the well-being and pathology of the host has garnered growing interest.In recent times,there has been a surge in understanding the mechanistic connections between the gut microbiota and cancer,particularly in relation to the genesis,progression,and therapeutic approaches for gastric cancer.The dysbiosis of the intestinal microbiome stands as a significant determinant in the etiology of gastric cancer.Currently,a preliminary consensus exists,although the precise mechanism remains incompletely understood.As research progresses,it becomes increasingly evident that intestinal flora significantly contributes to the therapeutic approach for gastric cancer.This paper gives a comprehensive review of the impact of intestinal flora on gastric cancer,examines the role of the intestinal microbiome in the management of gastric cancer,and elucidates the potential of utilizing the intestinal microbiome as an anti-tumor therapy,with an aim to furnish a point of reference and stimulate future research endeavors.
作者
张雅楠
崔曼莉
张灵敏
路宁
权昕
殷坤
李安娜
张明鑫
Ya-Nan Zhang;Man-Li Cui;Ling-Min Zhang;Ning Lu;Xin Quan;Kun Yin;An-Na Li;Ming-Xin Zhang(Xi’an Medical University,Xi’an 710000,Shaanxi Province,China;Department of Gastroenterology,The First Affiliated Hospital of Xi’an Medical University,Xi’an 710077,Shaanxi Province,China)
出处
《世界华人消化杂志》
CAS
2023年第22期933-939,共7页
World Chinese Journal of Digestology
基金
陕西省重点研发计划,No.2022JM-502和2023-YBSF-072
陕西省自然科学基础研究计划,No.2022JQ-980
陕西省卫生健康科研基金,No.2022E008.
关键词
肠道菌群
胃癌
放疗
化疗
益生菌
粪便移植
Gut microbiota
Gastric cancer
Chemotherapy
Radiotherapy
Probiotics
Fecal microbiota transplantation
