摘要
目的通过分析门静脉性胆道病(PB)患者的临床特征,旨在提高对PB的认识。方法收集吉林大学第一医院近年来诊断为PB的22例患者的临床资料,并对患者的临床表现、肝功能、腹部彩色多普勒超声、腹部CT和肝胆核磁共振成像进行分析,描述胆道异常的影像学表现,侧支循环类型和血栓形成部位等特点。结果本研究22例患者中,就诊的首发症状分别为:11例消化道出血,5例腹胀,3例腹痛,1例发热,1例腹部不适,1例牙龈出血。AST升高3例,ALT升高4例,GGT升高4例,ALP升高7例,CHE降低8例,Alb降低9例,Glo升高2例,TBil升高5例。20例患者有门静脉海绵样变性;2例存在门静脉系统血栓而无门静脉海绵样变性。22例患者均有胆管异常,其中2例仅为肝外胆管异常,12例仅为肝内胆管扩张,8例肝内外胆管均扩张。20例患者出现了不同部位的静脉曲张,其中19例主要表现为食管胃底静脉曲张,1例为胆囊周围静脉曲张,未见单纯肠系膜上静脉或脾静脉曲张。结论PB无典型的临床症状及肝功能指标变化,但影像学均可见不同部位胆管扩张、狭窄或畸形,需扩大样本量对其诊断及治疗方式进行进一步探索。
Objective This article aims to investigate the clinical features of portal biliopathy(PB)patients,in order to improve the understanding of PB.Methods Clinical data were collected from 22 patients who were diagnosed with PB in recent years in The First Hospital of Jilin University,and an analysis was performed for their clinical manifestations,liver function,abdominal color Doppler ultrasound,abdominal CT,and hepatobiliary magnetic resonance imaging.The imaging manifestations of biliary tract abnormalities were described,as well as the type of collateral circulation and the location of thrombosis.Results As for the initial symptom in these 22 patients,three were 11 patients with gastrointestinal bleeding,5 with abdominal distension,3 with abdominal pain,1 with fever,1 with abdominal discomfort,and 1 with gingival bleeding.There were 3 patients with an increase in aspartate aminotransferase,4 with an increase in alanine aminotransferase,4 with an increase in gamma-glutamyl transpeptidase,7 with an increase in alkaline phosphatase,8 with a reduction in cholinesterase,9 with a reduction in albumin,2 with an increase in globulin,and 5 with an increase in total bilirubin.Among the 22 patients,20 had cavernous transformation of the portal vein,and 2 had portal vein thrombosis without cavernous transformation.All 22 patients had bile duct abnormalities,among whom 2 had extrahepatic bile duct abnormalities alone,12 had intrahepatic bile duct dilatation alone,and 8 had dilatation of both intrahepatic and extrahepatic bile ducts.Varices at different sites were observed in 20 patients,among whom 19 had esophageal and gastric varices and 1 had peri-gallbladder varices,and no varices was observed in the superior mesenteric vein or the splenic vein.Conclusion There are no typical clinical symptoms and changes in liver function parameters in patients with PB,but radiological examination may show dilatation,stenosis,or malformation of the bile ducts at different parts.Therefore,it is necessary to expand the sample size to further
作者
耿雯倩
王崇
李航
牛俊奇
许芳
GENG Wenqian;WANG Chong;LI Hang;NIU Junqi;XU Fang(Department of Hepatology,The First Hospital of Jilin University,Changchun 130000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第11期2651-2656,共6页
Journal of Clinical Hepatology
基金
中国肝炎防治基金会天晴肝病研究基金(TQGB20210118)。
关键词
胆道疾病
超声检查
多普勒
彩色
磁共振成像
治疗学
Biliary Tract Diseases
Ultrasonography,Doppler,Color
Magnetic Resonance Imaging
Therapeutics
