摘要
目的:探讨干燥综合征(SS)患者血清微量元素水平变化及其与疾病严重程度的关系。方法:收集2022年10月至2023年8月于首都医科大学附属北京同仁医院眼科中心就诊的干眼患者65例(65只眼)。其中,男性5例(5只眼),女性60例(60只眼),年龄39~75岁,平均(54.3±18.4)岁。根据美国风湿病学会和欧洲风湿病联盟(ACR-EULAR)分类标准分为SS组和对照组。全部患者均进行眼表疾病指数(OSDI)评分和ACR-EULAR评分,检测下睑中央泪河高度(TMH)和泪膜破裂时间(TBUT),化学试验检测铜、锌、铁、钙及镁等血清微量元素。年龄、OSDI评分、TMH、TBUT、泪液分泌试验(ST)、眼表染色评分(OSS)及血清微量元素浓度等均服从正态分布,采用±s进行描述,组间比较采用独立样本t检验。性别采用例数描述,组间比较采用卡方检验。血清微量元素浓度与OSDI评分、TMH、TBUT、ST及OSS之间的相关性采用Pearson分析,与抗干燥综合征A抗体、抗干燥综合征B抗体、类风湿因子(RF)、抗核抗体(ANA)、唇腺活检及唾液腺流率之间的相关性采用Spearman分析。结果:SS组和对照组患者血清铜水平分别为(1.67±0.32)μg/ml和(1.12±0.51)μg/ml,SS组血清铜浓度高于对照组,差异有统计学意义(t=2.817,P<0.05)。SS组和对照组患者血清锌水平分别为(0.88±0.15)μg/ml和(0.99±0.13)μg/ml,SS组血清锌浓度低于对照组,差异有统计学意义(t=-2.245,P<0.05)。SS组和对照组患者血清铁水平分别为(0.87±0.12)μg/ml和(1.04±0.24)μg/ml,SS组血清铁浓度低于对照组,差异有统计学意义(t=-2.087,P<0.05)。SS组和对照组患者血清钙水平分别为(77.22±12.15)μg/ml和(92.07±15.42)μg/ml,SS组血清钙浓度低于对照组,差异有统计学意义(t=-2.312,P<0.05)。SS组和对照组患者血清镁水平分别为(17.33±2.12)μg/ml和(20.51±3.14)μg/ml,SS组血清镁浓度低于对照组,差异有统计学意义(t=-3.507,P<0.05)。血清铜与唇腺活检及OSDI呈正相关
Objective To investigate the levels of serum trace element in patients with Sjogren's Syndrome(SS)and its correlations with the severity of SS.Methods Sixty-five dry eye patients(65 eyes)registered the Eye Center of Beijing Tongren Hospital affiliated to Capital Medical University from October 2022 to August 2023 were selected.Among them,there were 5 males(5 eyes)and 60 females(60 eyes),aged 39 to 75 years,with an average age of(54.3±18.4)years.According to the classification standards of the American Rheumatology Society and the European Rheumatology Alliance(ACR-EULAR),they were divided into SS group and the control group.All patients were scored with the eye surface disease index(OSDI)and ACR-EULAR scores,and the central tear river height(TMH)and tear film rupture time(TBUT)of the lower eyelid were measured.The serum trace elements such as copper,zinc,iron,calcium,and magnesium were detected by chemical tests.Age,OSDI score,TMH,TBUT,tear secretion test(ST),eye surface staining score(OSS),and serum trace element concentration conforming to normal distribution were described by x±S,and compared by independent sample t test for groups.Gender was described using case numbers,and compared by chi square tests.The correlation between serum trace element concentrations and OSDI scores,TMH,TBUT,ST,and OSS was analyzed using Pearson analysis.The correlation between serum trace element concentrations and anti Sjogren's syndrome A antibodies,anti Sjogren's syndrome B antibodies,rheumatoid factor(RF),antinuclear antibodies(ANA),labial gland biopsy,and salivary gland flow rate was analyzed using Spearman analysis.Results The serum copper levels in SS group and control group were(1.67±0.32)μg/ml and(1.12±0.51)μg/ml,respectively;the former concentration was higher than the latter.There was a statistically significant difference in the serum copper levels between groups(t=2.817,P<0.05).The serum zinc levels of patients in SS group and control group were(0.88±0.15)μg/ml and(0.99±0.13)μg/ml,respectively;the former conc
作者
郝然
魏姗珊
吴倩如
李学民
翟长斌
Hao Ran;Wei Shanshan;Wu Qianru;Li Xuemin;Zhai Changbin(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100730,China;Department of Ophthalmology,Peking University Third Hospital,Beijing 100191,China)
出处
《中华眼科医学杂志（电子版）》
2023年第4期215-220,共6页
Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
基金
国家自然科学基金青年项目(82201145)。
关键词
干燥综合征
微量元素
免疫
炎症
Sjogren's syndrome
Trace elements
Immunity
Inflammation
