摘要
目的分析扩大胰十二指肠切除术在胰腺癌治疗中的临床疗效。方法选取2019年10月—2022年10月在联勤保障部队第970医院接受手术治疗的75例胰腺癌患者为研究对象。根据患者接受的不同手术方法分组,对照组(35例)常规胰十二指肠切除手术,研究组(40例)应用扩大胰十二指肠切除术治疗,比较两组临床情况,术后并发症,术后恢复情况,以及治疗前后T细胞亚群水平变化。结果两组患者术中出血量比较,差异无统计学意义(P>0.05)。研究组手术操作时间为(306.79±22.65)min,比对照组更短,淋巴结清扫数目为(14.08±3.21)个,比对照组更多,差异有统计学意义(t=4.554、4.846,P<0.05)。两组患者术后排气时间、下床活动时间、住院时间比较,差异无统计学意义(P>0.05)。两组患者术后并发症的总发生率比较,差异无统计学意义(P>0.05)。治疗后,研究组CD3^(+)、CD4^(+)水平高于对照组,差异有统计学意义(P<0.05)。结论胰腺癌治疗中,应用扩大胰十二指肠切除术治疗,可提高清扫数量,提高治疗效果,不会因扩大而造成术后并发症发生率增加,且术后CD3^(+)、CD4^(+)水平恢复速度也较快,不会对出血量产生过大影响。
Objective To analyze the clinical effect of extended pancreaticoduodenectomy in the treatment of pancreatic cancer.Methods Seventy-five patients with pancreatic cancer who underwent surgical treatment at the 970 Hospital of the Joint Logistics Support Force from October 2019 to October 2022 were selected as study subjects.Patients were divided into groups according to different surgical methods,the control group(35 cases)underwent routine pancreaticoduodenectomy,and the study group(40 cases)underwent extended pancreaticoduodenectomy.The clinical situation,postoperative complications,postoperative recovery,and changes of T cell subsets before and after treatment were compared between the two groups.Results The intraoperative blood loss between the two groups were compared,and the difference was not statistically significant(P>0.05).The operation time of the study group was(306.79±22.65)min,which was shorter than that of the control group,the number of lymph nodes dissection was(14.08±3.21),which was more than that of the control group,and the difference was statistically significant(t=4.554,4.846,P<0.05).The postoperative exhaust time,the time of getting out of bed and the time of hospitalization were were compared between two groups,and the difference was not statistically significant(P>0.05).There was no statistically significant difference in the total incidence of postoperative complications between the two groups(P>0.05).After treatment,the levels of CD3^(+)and CD4^(+)in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of pancreatic cancer,the application of extended pancreaticoduodenectomy can increase the number of dissection and improve the therapeutic effect,and the incidence of postoperative complications will not increase due to the expansion,and the recovery rate of postoperative CD3^(+)and CD4^(+)levels is also faster,which will not have a large impact on the amount of blood loss.
作者
杨强
张豪洁
YANG Qiang;ZHANG Haojie(Department of Hepatobiliary Surgery,970th Hospital of Joint Logistic Support Force,Yantai,Shandong Province,264002 China)
出处
《系统医学》
2023年第16期122-125,共4页
Systems Medicine
关键词
胰十二指肠切除手术
胰腺癌
临床疗效
术中出血量
Pancreaticoduodenectomy
Pancreatic cancer
Clinical effect
Intraoperative blood loss
