摘要
目的研究术前磁共振成像(MRI)及钼靶影像下乳腺癌生物学特征与保乳手术中切缘阳性的相关性。方法回顾性选取2022年1月至2023年1月新疆医科大学附属中医医院收治的行乳腺癌保乳术治疗的患者60例,根据术中病理切缘结果将患者分为切缘阴性组(n=38)和切缘阳性组(n=22)。比较两组患者临床资料、临床病理特征及MRI、钼靶影像下乳腺癌生物学特征;采用Logistic回归分析对乳腺癌患者保乳手术中切缘阳性的影响因素进行分析。结果两组患者肿瘤家族史、年龄、肿瘤大小、绝经、TNM分期、肿瘤位置、淋巴结转移、雌激素受体、脉管内癌栓、病理类型及组织学分级进行比较,差异均无统计学意义(P>0.05)。切缘阳性组患者人类表皮生长因子受体2(HER-2)阴性及不确定比率低于切缘阴性组,切缘阳性组患者HER-2阳性比率高于切缘阴性组,差异均有统计学意义(P<0.05)。MRI特征比较:两组患者乳腺纤维腺体组织(FGT)分类、对侧背景实质强化(BPE)情况、同侧BPE情况、肿块边缘情况比较,差异均无统计学意义(P>0.05);切缘阳性组多中心病灶比率高于切缘阴性组,差异有统计学意义(P<0.05)。钼靶影像特征比较:两组患者病灶边缘、病灶形态情况进行比较,差异均无统计学意义(P>0.05),切缘阳性组患者肿块较切缘阴性组更大,差异有统计学意义(P<0.05)。Logistic回归分析结果显示:肿块大小、多中心病灶是乳腺癌患者保乳手术中切缘阳性的影响因素(P<0.05)。结论MRI特征中多中心病灶、钼靶影像特征中肿块大小是保乳手术中切缘阳性的影响因素。
Objective To study the correlation between biological characteristics of breast cancer under preoperative magnetic resonance imaging(MRI)and positive margins in breast-conserving surgery.Methods Sixty patients treated with breast conserving surgery for breast cancer in Affiliated Hospital of Traditional Chinese Medicine from January 2022 to January 2023 were retrospectively selected.The patients were divided into the negative margin group(n=38)and the positive margin group(n=22)according to the pathological margin results during surgery.The general clinical data,clinicopathological characteristics,MRI and molybdenum target imaging were compared between the two groups.The influencing factors of positive margin in breast conserving surgery for breast cancer patients were analyzed by Logistic regression analysis.Results There were no statistically significant differences between the two groups in terms of tumor family history,age,tumor size,menopause,TNM staging,tumor location,lymph node metastasis,estrogen receptor,intravascular tumor thrombus,pathological type,and histological grading(P>0.05).The negative and uncertain rate of human epidermal growth factor receptor 2(HER-2)in patients with positive margins was lower than that in patients with negative margins,and the positive rate of HER-2 was higher than that in patients with negative margins,the differences were statistically significant(P<0.05).MRI features:there were no statistically significant differences in the classification of breast fibroglandular tissue(FGT),contralateral background parenchymal enhancement(BPE),ipsilateral BPE,and tumor margin between the two groups of patients(P>0.05);the proportion of multicenter lesions in the positive margin group was higher than that in the negative margin group,the difference was statistically significant(P<0.05).Molybdenum target imaging features:Theres were no statistically significant differences in the edge and shape of the lesion between the two groups of patients(P>0.05),the tumor in the positive margin grou
作者
康晶
王蓓
薛志伟
宋丽俊
栾丽
KANG Jing;WANG Bei;XUE Zhi-wei(Department of Medical Imaging,Affiliated Hospital of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi Xinjiang 830000,China)
出处
《临床和实验医学杂志》
2023年第20期2222-2225,共4页
Journal of Clinical and Experimental Medicine
基金
新疆维吾尔自治区自然科学基金课题(编号:2016D01C133)。
关键词
磁共振成像
乳腺肿瘤
钼靶影像
保乳手术切缘阳性
临床病理特征
中心病灶
肿块大小
Magnetic resonance imaging
Breast diseases
Molybdenum target imaging
Positive margin for breast preservation surgery
Clinicopathological features
Central lesion
Mass size
