摘要
目的探讨奥美拉唑三联疗法联合中药穴位贴敷治疗脾胃虚寒型胃溃疡的临床疗效。方法选取2020年1月至2022年1月信阳市平桥区中医院收治的80例脾胃虚寒型胃溃疡患者作为研究对象,按照不同治疗方法将其分为观察组(40例)和对照组(40例),观察组患者采用奥美拉唑三联疗法联合中药穴位贴敷治疗,对照组患者单纯采用奥美拉唑三联疗法治疗,对比观察两组患者血清胃肠激素及炎症因子水平、中医症状积分、临床疗效以及不良反应发生情况。结果治疗2个月后,观察组患者血清胃动素(MOT)、胃泌素(GAS)、白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)水平以及腹痛、腹胀、反酸嗳气评分均明显低于对照组(t=6.407、4.948、11.432、8.875、13.345、2.656、3.134、3.251,P<0.001、P<0.001、P<0.001、P<0.001、P<0.001、P=0.010、P=0.002、P=0.002),临床疗效明显优于对照组(Z=-1.976,P=0.048)。治疗期间,观察组患者不良反应发生率为7.50%,与对照组患者的不良反应发生率12.50%无明显差异(χ^(2)=0.556,P=0.456)。结论在奥美拉唑三联疗法治疗的基础上联合应用中药穴位贴敷治疗脾胃虚寒型胃溃疡,可明显改善胃肠激素水平,减轻炎症反应程度,缓解临床症状,提高治疗效果,安全性较高。
Objective To study the clinical efficacy of Omeprazole triple therapy combined with Chinese medicine acupoint application in the treatment of gastric ulcer of spleen and stomach deficiency⁃cold syndrome.Methods 80 patients with gastric ulcer of spleen and stomach deficiency⁃cold syndrome,admitted to Xinyang Pingqiao District Hospital of Traditional Chinese Medicine from January 2020 to January 2022,were enrolled as research subjects and divided,based on the treatments they received,into study group(n=40)and control group(n=40).Patients in the study group were treated with Omeprazole triple therapy combined with Chinese medicine acupoint application,while patients in the control group were treated with Omeprazole triple therapy alone.The levels of serum gastrointestinal hormones and inflammatory factors,TCM syndrome scores,clinical efficacy and occurrence of adverse reactions of patients were compared between the two groups.Results After two months of treatment,as compared with the control group,the levels of serum motilin(MOT),gastrin(GAS),interleukin(IL)⁃6,IL⁃8,tumor necrosis factor⁃α(TNF⁃α)and the scores of abdominal pain,abdominal distension,acid regurgitation and belching of patients in the study group were all significantly lower(t=6.407,4.948,11.432,8.875,13.345,2.656,3.134 and 3.251,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,P=0.010,P=0.002,P=0.002),and the clinical efficacy was obviously better in the study group(Z=-1.976,P=0.048).During the course of treatment,the incidence of adverse reactions of patients was 7.50%in the study group,which showed no significant difference compared with the corresponding 12.50%in the control group(χ^(2)=0.556,P=0.456).Conclusion The combined application of Chinese medicine acupoint application on the basis of the Omeprazole triple therapy in the treatment of gastric ulcer of spleen and stomach deficiency⁃cold syndrome can effectively improve the levels of gastrointestinal hormones,reduce inflammatory response,alleviate clinical symptoms,and achieve good clin
作者
吕传芳
赵燕
张家家
LV Chuanfang;ZHAO Yan;ZHANG Jiajia(Internal Department of Integrated Chinese-Western Medicine,Xinyang Pingqiao District Hospital of Traditional Chinese Medicine,Xinyang,Henan 464000,China)
出处
《中国烧伤创疡杂志》
2023年第6期483-487,共5页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
中药
穴位贴敷
奥美拉唑三联疗法
脾胃虚寒
胃溃疡
胃肠激素
炎症反应
Chinese medicine
Acupoint application
Omeprazole triple therapy
Spleen and stomach deficiency⁃cold syndrome
Gastric ulcer
Gastrointestinal hormone
Inflammatory response
