摘要
目的:观察清胃散联合甲硝唑治疗胃火炽热型慢性牙周炎患者的效果。方法:选取2020年1月至2023年1月郑州市口腔医院综合科收治的96例慢性牙周炎患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各48例。对照组采用甲硝唑片治疗,观察组在对照组基础上采用清胃散治疗,比较两组临床疗效,治疗前后牙周相关指标[牙菌斑指数(PLI)、牙龈指数(GI)、龈沟出血指数(SBI)]水平、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、前列腺素E2(PGE2)]水平,不良反应发生率,以及复发率。结果:观察组治疗总有效率为93.75%(45/48),高于对照组的72.92%(35/48),差异有统计学意义(P<0.05);治疗后,两组PLI、GI、SBI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组TNF-α、IL-8、PGE2水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论:清胃散联合甲硝唑治疗胃火炽热型慢性牙周炎患者可提高治疗总有效率,降低牙周相关指标水平、炎性因子水平和复发率,其效果优于单纯甲硝唑片治疗。
Objective:To observe effects of Qingwei powder combined with Metronidazole in treatment of patients with chronic periodontitis of blazing stomach fire type.Methods:A prospective study was conducted on 96 patients with chronic periodontitis admitted to the Comprehensive Department of Hospital of Zhengzhou City from January 2020 to January 2023.According to the random number table method,they were divided into control group and observation group,48 cases in each group.The control group was treated with Metronidazole tablets,while the observation group was treated with Qingwei powder on the basis of that of the control group.The clinical efficacy,the periodontal related indexes[plaque index(PLI),gingival index(GI),sulcus bleeding index(SBI)]levels,the inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),prostaglandin E2(PGE2)]levels before and after the treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The total effective rate of the observation group was 93.75%(45/48),which was higher than 72.92%(35/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of PLI,GI and SBI in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of TNF-α,IL-8 and PGE2 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusions:Qingwei powder combined with Metronidazole can improve the total effective rate of treatment,reduce the levels of periodontal related ind
作者
刘伟伟
王淑敏
韩丽纳
LIU Weiwei;WANG Shumin;HAN Lina(Comprehensive Department of Hospital of Zhengzhou City,Zhengzhou 450000 Henan;Department of Stomatology of the 989th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army,Luoyang 471031 Henan,China;Department of General Surgery of Yellow River Central Hospital of Yellow River Water Resources Commission,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2023年第21期91-93,103,共4页
Medical Journal of Chinese People’s Health
关键词
牙周炎
清胃散
甲硝唑
炎性因子
不良反应
复发率
Periodontitis
Qingwei powder
Metronidazole
Inflammatory factor
Adverse reaction
Recurrence
